Document Detail

Ultrasound-guided procedures for prenatal diagnosis and therapy.
MedLine Citation:
PMID:  15062449     Owner:  NLM     Status:  MEDLINE    
Ultrasonography has expanded the capabilities of perinatologists to examine,test, and treat the fetus. Amniocentesis and CVS are safe and widely available procedures, which can be used to diagnose a multitude of abnormalities through karyotype analysis and molecular studies. CVS allows earlier diagnosis, but both procedures can provide highly accurate results in the first half of pregnancy. Cordocentesis has fewer indications, but allows direct laboratory testing of fetal blood. Fetocentesis and fetal biopsy are reserved for limited indications, but can play a crucial role in the diagnosis of some conditions, which cannot be assessed less invasively. Fetal transfusion is an important tool in the treatment of isoimmunization, some other forms of fetal anemia, and alloimmune thrombocytopenia. Amnioreduction is a commonly used procedure for the treatment of polyhydramnios and TTTS. Multifetal reduction and selective termination offer previously unavailable options to patients carrying multiple gestations. Fetal shunts can reduce perinatal morbidity and mortality in cases of bladder outlet obstruction and hydrothorax. The limited experience with cord ligation procedures and balloon valvuloplasty suggests these relatively new procedures may serve a greater role in the future as techniques are improved. By providing guidance for all of these procedures, real-time ultrasonography has revolutionized prenatal diagnosis and therapy; it will continue to be a crucial component in evaluating and treating complicated pregnancies.
Steven J Ralston; Sabrina D Craigo
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Obstetrics and gynecology clinics of North America     Volume:  31     ISSN:  0889-8545     ISO Abbreviation:  Obstet. Gynecol. Clin. North Am.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-05-27     Completed Date:  2004-10-05     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8709551     Medline TA:  Obstet Gynecol Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  101-23     Citation Subset:  IM    
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Tufts University School of Medicine, Tufts-New England Medical Center, 750 Washington Street, Box 360, Boston, MA 02111, USA.
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MeSH Terms
Amniotic Fluid
Biopsy / adverse effects,  methods
Blood Transfusion, Intrauterine / methods
Cordocentesis / adverse effects,  methods
Fetal Diseases / pathology,  therapy
Pregnancy Reduction, Multifetal / adverse effects,  methods
Prenatal Diagnosis / adverse effects,  methods*

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