Document Detail


Ultrasound-guided percutaneous microwave ablation for submucosal uterine fibroids.
MedLine Citation:
PMID:  24316137     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
STUDY OBJECTIVE: To prospectively evaluate the efficiency and safety of ultrasound (US)-guided percutaneous microwave ablation (PMWA) in treating symptomatic submucosal uterine fibroids (SSUFs).
DESIGN: Self-control study (Canadian Task Force classification II-1).
SETTING: A single centre (Department of Interventional Ultrasonics, General Hospital of Chinese PLA, Beijing, China).
PATIENTS: Twenty-two premenopausal women with 22 SSUFs.
INTERVENTION: All of the patients underwent US-guided PMWA.
MEASUREMENTS: PMWA was performed on 22 premenopausal women with 22 SSUFs. The mean patient age was 42.00±4.60 years (95% CI, 39.96-44.04). Five SSUFs were identified as type 0, 7 as type I and 10 as type II. Contrast-enhanced ultrasound and magnetic resonance imaging were performed pre- and post-operation. The volume of the fibroids, the patients' haemoglobin levels and scores on the Uterine Fibroid Symptom and Quality of Life (UFS-QOL) were recorded before and at 3 and 12 months after ablation. Complications were also recorded.
RESULTS: All patients completed therapy with a single ablation. The baseline diameter of the SSUFs was 4.90±1.60 cm. The average fibroid volume reduction rate was 81.46±16.33% (95%CI, 73.06-89.86%) at 3 months (P<.001) and reached 90.00±9.79% (95%CI, 85.07-95.13%) at 12 months (P<.001). Three months after ablation, the patients' haemoglobin levels increased from 88.64±21.87 g/L (95%CI, 78.94-98.34) to 123.21±15.77 g/L (95%CI, 115.10-131.32) (P<.001) and remained stable at 12 months, with a value of 125.92±14.90 g/L (95%CI, 117.98-133.86). The scores on UFS-QOL were comparable, with normal levels observed at 1 year. No major complications were observed. Finally, 9 patients discharged necrotic masses.
CONCLUSION: PMWA appears to be effective and safe for submucosal fibroids.
Authors:
Yang Yu; Zhang Jing; Han Zhi-Yu; Yu Ming-An; Ma Xia; Zhou Hong-Yu; Hao Yan-Li; Zhao Lan; Dong Xue-Juan; Ge Hai-Long
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-12-3
Journal Detail:
Title:  Journal of minimally invasive gynecology     Volume:  -     ISSN:  1553-4669     ISO Abbreviation:  J Minim Invasive Gynecol     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-12-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101235322     Medline TA:  J Minim Invasive Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 AAGL. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Interventional Ultrasonics, General Hospital of Chinese PLA.
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