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Ultrasound-guided fine-needle aspiration for solid thyroid nodules larger than 10 mm: correlation between sonographic characteristics at the needle tip and nondiagnostic results.
MedLine Citation:
PMID:  23990249     Owner:  NLM     Status:  Publisher    
The objective of this study was to investigate the effect of the ultrasonographic (US) characteristics and ultrasound elastography (UE) patterns on the probability of a nondiagnostic result when performing ultrasound-guided fine-needle aspiration (UG-FNA) cytological sampling of solid thyroid nodules larger than 10 mm, to determine the efficacy of needle tip localization in UG-FNA. We retrospectively reviewed the cytological results of 710 samples from 355 patients. We compared the US characteristics and UE patterns between nodules with nondiagnostic and diagnostic results, using univariate and multivariate analyses. Among the 710 samples, 81 samples (11.4 %) from 41 patients had nondiagnostic results. According to multivariate analysis, the combinations of hypoechogenicity with avascularity [odds ratio (OR) = 2.42; 95 % confidence interval (CI) 1.37-3.72; p < 0.05], hypoechogenicity with the "hard pattern" (OR = 2.12; 95 % CI 1.58-4.59; p < 0.05), and hypoechogenicity with avascularity and the hard pattern (OR = 2.61; 95 % CI 1.40-5.21; p < 0.05) were risk factors that increased the incidence of nondiagnostic results in UG-FNA. UG-FNA was more likely to yield nondiagnostic results when the needle tip sampling region displayed hypoechogenicity and avascularity in US and the hard pattern in UE.
Hongxun Wu; Bingjie Zhang; Yaping Zang; Jun Wang; Beilin Zhu; Yuelong Cao; Qianyun Liu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-8-29
Journal Detail:
Title:  Endocrine     Volume:  -     ISSN:  1559-0100     ISO Abbreviation:  Endocrine     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-8-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9434444     Medline TA:  Endocrine     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Ultrasound, Jiang Yuan Hospital Affiliated with the Jiangsu Institute of Nuclear Medicine (Key Laboratory of Nuclear Medicine, Ministry of Health/Jiangsu Key Laboratory of Molecular Nuclear Medicine), 20 Qianrong Rd, Wuxi, 214063, Jiangsu, China,
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