Document Detail

Ultrasound-guided botulinum toxin injections for treatment of drooling.
MedLine Citation:
PMID:  21600865     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate the efficacy of treatment of drooling by ultrasound-guided botulinum toxin injection of the salivary glands and to determine the optimal modalities of this procedure.
PATIENTS AND METHODS: This study is a retrospective review of patients treated for drooling by injection of 100 units of Botox(®) into the parotid and submaxillary glands between 2002 and 2008. Efficacy was evaluated by a quality of life questionnaire six weeks after the injections.
RESULTS: One hundred and eleven injection sessions were performed in 70 patients aged one to 84 years with a beneficial effect in 66% of cases. The most effective protocol was injection of 20 units of botulinum toxin into each submaxillary gland and 30 units of toxin into each parotid gland.
CONCLUSION: The treatment of drooling by Botox(®) injections into salivary glands is effective. The authors propose ultrasound-guided injection of both submaxillary glands and both parotid glands. These injections can be repeated in the case of recurrence of drooling.
R Breheret; A Bizon; C Jeufroy; L Laccourreye
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Publication Detail:
Type:  Journal Article     Date:  2011-05-19
Journal Detail:
Title:  European annals of otorhinolaryngology, head and neck diseases     Volume:  128     ISSN:  1879-730X     ISO Abbreviation:  Eur Ann Otorhinolaryngol Head Neck Dis     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-07     Completed Date:  2012-04-05     Revised Date:  2014-10-30    
Medline Journal Info:
Nlm Unique ID:  101531465     Medline TA:  Eur Ann Otorhinolaryngol Head Neck Dis     Country:  France    
Other Details:
Languages:  eng     Pagination:  224-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Masson SAS. All rights reserved.
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MeSH Terms
Aged, 80 and over
Botulinum Toxins, Type A / administration & dosage*
Child, Preschool
Middle Aged
Neurotoxins / administration & dosage*
Parotid Gland*
Retrospective Studies
Sialorrhea / drug therapy*
Submandibular Gland*
Ultrasonography, Interventional*
Young Adult
Reg. No./Substance:
0/Neurotoxins; 0/onabotulinumtoxinA; EC Toxins, Type A

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