| Ultrasound characterization of red blood cell aggregation with intervening attenuating tissue-mimicking phantoms. | |
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MedLine Citation:
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PMID: 20136231 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The analysis of the ultrasonic frequency-dependent backscatter coefficient of aggregating red blood cells reveals information about blood structural properties. The difficulty in applying this technique in vivo is due to the frequency-dependent attenuation caused by intervening tissue layers that distorts the spectral content of signals backscattered by blood. An optimization method is proposed to simultaneously estimate tissue attenuation and blood structure properties, and was termed the structure factor size and attenuation estimator (SFSAE). An ultrasound scanner equipped with a wide-band 25 MHz probe was used to insonify porcine blood sheared in both Couette and tubular flow devices. Since skin is one of the most attenuating tissue layers during in vivo scanning, four skin-mimicking phantoms with different attenuation coefficients were introduced between the transducer and the blood flow. The SFSAE gave estimates with relative errors below 25% for attenuations between 0.115 and 0.411 dBMHz and kR<2.08 (k being the wave number and R the aggregate radius). The SFSAE can be useful to examine in vivo and in situ abnormal blood conditions suspected to promote pathophysiological cardiovascular consequences. |
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Authors:
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Emilie Franceschini; François T H Yu; François Destrempes; Guy Cloutier |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of the Acoustical Society of America Volume: 127 ISSN: 1520-8524 ISO Abbreviation: J. Acoust. Soc. Am. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-08 Completed Date: 2010-06-24 Revised Date: 2011-07-22 |
Medline Journal Info:
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Nlm Unique ID: 7503051 Medline TA: J Acoust Soc Am Country: United States |
Other Details:
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Languages: eng Pagination: 1104-15 Citation Subset: IM |
Affiliation:
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Laboratory of Biorheology and Medical Ultrasonics, University of Montreal Hospital Research Center, Pavillon JA de Seve Room Y-1619, 2099 Alexandre de Seve, Montreal, Quebec H2L 2W5, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Animals Erythrocyte Aggregation* Erythrocytes / physiology*, ultrasonography* Phantoms, Imaging Signal Processing, Computer-Assisted* Skin / ultrasonography Skin Physiological Phenomena Swine Ultrasonography / instrumentation, methods* |
| Grant Support | |
ID/Acronym/Agency:
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CMI-72323//Canadian Institutes of Health Research; MOP-84358//Canadian Institutes of Health Research; R01HL078655/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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