Document Detail


Ultrasound carotid artery intima-media thickness assessment for progression of atherosclerosis in lipid intervention studies.
MedLine Citation:
PMID:  18311661     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Atherosclerotic cardiovascular disease is the number one cause of death in Western countries and is a rapidly growing problem worldwide. The majority of patients who present with acute coronary syndrome often have a low cardiovascular risk score, which is insufficient to warrant treatment prior to an acute coronary event. Alternatively, some high risk individuals never develop cardiovascular events. Identification of individuals who are truly at risk before an acute coronary event is critical. The long subclinical incubation period of atherosclerosis and the early involvement of the vessel wall in the disease provides an opportunity to evaluate the presence of atherosclerosis by imaging the arterial wall and to initiate treatment measures prior to an acute coronary event. The assessment of the thickness of the intima-media layer of the vessel wall, as well as detection of early plaques by ultrasound, is non-invasive and is the most sensitive, reliable, and safe method to detect those at risk. It is also the most validated method to detect progression of atherosclerosis. Evaluation of atherosclerosis progression by this technique has been used in large clinical trial settings, however, improvement in imaging and measurement technology may make this suitable for use in individual patients for therapeutic validity both in primary and secondary care settings.
Authors:
Tasneem Z Naqvi
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in investigational drugs (London, England : 2000)     Volume:  9     ISSN:  1472-4472     ISO Abbreviation:  Curr Opin Investig Drugs     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-03     Completed Date:  2008-05-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100965718     Medline TA:  Curr Opin Investig Drugs     Country:  England    
Other Details:
Languages:  eng     Pagination:  256-64     Citation Subset:  IM    
Affiliation:
Cedars-Sinai Medical Center, Division of Cardiology, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA. tasneem.naqvi@cshs.org
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MeSH Terms
Descriptor/Qualifier:
Animals
Anticholesteremic Agents / therapeutic use
Antilipemic Agents / therapeutic use*
Atherosclerosis / drug therapy*,  ultrasonography*
Carotid Arteries / ultrasonography*
Cholesterol, HDL / blood,  physiology
Clinical Trials as Topic
Disease Progression
Humans
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Antilipemic Agents; 0/Cholesterol, HDL

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