| Ultrasound carotid artery intima-media thickness assessment for progression of atherosclerosis in lipid intervention studies. | |
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MedLine Citation:
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PMID: 18311661 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Atherosclerotic cardiovascular disease is the number one cause of death in Western countries and is a rapidly growing problem worldwide. The majority of patients who present with acute coronary syndrome often have a low cardiovascular risk score, which is insufficient to warrant treatment prior to an acute coronary event. Alternatively, some high risk individuals never develop cardiovascular events. Identification of individuals who are truly at risk before an acute coronary event is critical. The long subclinical incubation period of atherosclerosis and the early involvement of the vessel wall in the disease provides an opportunity to evaluate the presence of atherosclerosis by imaging the arterial wall and to initiate treatment measures prior to an acute coronary event. The assessment of the thickness of the intima-media layer of the vessel wall, as well as detection of early plaques by ultrasound, is non-invasive and is the most sensitive, reliable, and safe method to detect those at risk. It is also the most validated method to detect progression of atherosclerosis. Evaluation of atherosclerosis progression by this technique has been used in large clinical trial settings, however, improvement in imaging and measurement technology may make this suitable for use in individual patients for therapeutic validity both in primary and secondary care settings. |
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Authors:
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Tasneem Z Naqvi |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in investigational drugs (London, England : 2000) Volume: 9 ISSN: 1472-4472 ISO Abbreviation: Curr Opin Investig Drugs Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-03-03 Completed Date: 2008-05-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100965718 Medline TA: Curr Opin Investig Drugs Country: England |
Other Details:
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Languages: eng Pagination: 256-64 Citation Subset: IM |
Affiliation:
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Cedars-Sinai Medical Center, Division of Cardiology, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA. tasneem.naqvi@cshs.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticholesteremic Agents / therapeutic use Antilipemic Agents / therapeutic use* Atherosclerosis / drug therapy*, ultrasonography* Carotid Arteries / ultrasonography* Cholesterol, HDL / blood, physiology Clinical Trials as Topic Disease Progression Humans Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Antilipemic Agents; 0/Cholesterol, HDL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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