| Ultrasound-assisted skin diagnostics. | |
| | |
MedLine Citation:
|
PMID: 18189657 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
The biomolecular composition of human skin, represented by a multitude of lipids, proteins, nucleic acids, and other miscellaneous molecules, is a sensitive indicator of skin's local health, as well as the body's systemic health. However, this information is not easily accessible, and consequently not used in the current diagnostic methods. To address the lack of quantitative methods for non-invasive skin diagnostics, herein, we describe the use of ultrasound to rapidly extract biological markers from skin. Specifically, we extracted several types of proteins (keratins, beta-actin, cytokines, and others), lipids (cholesterol, ceramides, fatty acids, and others), nucleic acids, small molecules (natural moisturizing factors and exogenous molecules), and microbes enabling us to create skin's unique biomolecular signature. The extracted biomolecules showed quantitative correlations with their composition in the epidermal skin. Extraction of these entities from skin using our method is convenient and reproducible, thus making it an advantageous alternative to biopsy and tape-stripping. By quantifying changes in skin's biomolecular profile, we report several specific in vivo applications of our method for assessing chemical-induced skin irritation, atopic dermatitis, and psoriasis in animal models. As a corollary to this technique, measurement of skin's drug bioavailability in rats is also demonstrated. |
| | |
Authors:
|
Sumit Paliwal; Makoto Ogura; Samir Mitragotri |
Related Documents
:
|
15826497 - Interaction of resveratrol and genistein with nucleic acids. 708697 - Rapid, single-step purification of restriction endonucleases on cibacron blue f3ga-agar... 5004197 - Appearance of a methylated ribonucleic acid on illumination of euglena gracillis cells ... 234157 - Simple process for the reduction in the nucleic acid content in yeast. 10561507 - Peroxyl radicals are potential agents of lignin biodegradation. 965347 - Ion selective method for the determination of nitrite in smoked fish. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of the Acoustical Society of America Volume: 122 ISSN: 1520-8524 ISO Abbreviation: J. Acoust. Soc. Am. Publication Date: 2007 Nov |
Date Detail:
|
Created Date: 2008-01-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7503051 Medline TA: J Acoust Soc Am Country: United States |
Other Details:
|
Languages: eng Pagination: 2956 Citation Subset: IM |
Affiliation:
|
Dept. of Chemical Eng., Univ. of California, Santa Barbara, CA 93106. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Acoustic hemostasis: Underlying mechanisms.
Next Document: Spatiotemporal response of mammalian cells to sonoporation measured using calcium imaging.