| Ultrasound-assisted click chemistry in continuous flow. | |
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MedLine Citation:
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PMID: 21927797 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We present a study on ultrasound-promoted click chemistry reactions in a meso-flow reactor synthesis system with a copper reactor and a custom sonication piezoelectric transducer. Copper catalyzed Huisgen 1,3-dipolar cycloadditions were studied in flow with this system. Our results demonstrate that 1,4-disubstituted 1,2,3-triazole products can be generated at low temperatures and with short reaction time in good yield, due to the rate enhancement effect of sonication. |
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Authors:
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Noah P Tu; Jill E Hochlowski; Stevan W Djuric |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-17 |
Journal Detail:
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Title: Molecular diversity Volume: - ISSN: 1573-501X ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9516534 Medline TA: Mol Divers Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Medicinal Chemistry Technologies, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL, 60064, USA, noah.tu@abbott.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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