Document Detail


Ultrasonography of the normal kidney in the cynomolgus monkey (Macaca fascicularis): morphologic and Doppler findings.
MedLine Citation:
PMID:  10950455     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to obtain sonographic measures of normal kidneys in cynomolgus monkeys (Macaca fascicularis). The kidneys of 27 healthy female cynomolgus monkeys were examined with two-dimensional, duplex and power Doppler under sedation or general anesthesia. Except for shape and sinus echogenicity, the kidneys of the cynomolgus monkey are morphologically similar to those of humans. Left kidney volume estimations (mean, 5.1 cm3) were significantly smaller (P<0.001) than those of the right (mean, 5.9 cm3), and both increased significantly with increasing body weight (P<0.05, r = 0.408). The mean resistive index (RI) of ketamine-sedated monkeys was 0.54, with an upper limit of 0.74 for the renal artery. The mean RI under general anesthesia was 0.65, with an upper limit of 0.77. Morphologic and Doppler ultrasound assessments of the kidneys can be consistently performed in the conscious cynomolgus monkey, and anesthesia can have hemodynamic effects that alter the Doppler arterial waveform.
Authors:
L Gaschen; K Menninger; H J Schuurman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medical primatology     Volume:  29     ISSN:  0047-2565     ISO Abbreviation:  J. Med. Primatol.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-12-04     Completed Date:  2000-12-04     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0320626     Medline TA:  J Med Primatol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  76-84     Citation Subset:  IM    
Affiliation:
Novartis Pharma AG, Transplantation Research, Basel, Switzerland. lorrie.gaschen@pharma.novartis.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Kidney / anatomy & histology*,  ultrasonography*
Kidney Transplantation
Macaca fascicularis / anatomy & histology*
Ultrasonography, Doppler / methods,  veterinary
Ultrasonography, Doppler, Duplex / methods,  veterinary

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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