Document Detail

Ultrasonography and magnetic resonance imaging in Leigh disease.
MedLine Citation:
PMID:  2242175     Owner:  NLM     Status:  MEDLINE    
An infant with Leigh disease, who was the younger sister of a similarly affected infant, had been examined before the onset of the disease. Ultrasonography revealed hyperechoic lesions in the putamen and caudate nucleus during the preclinical stage. At onset, these changes extended into the cerebral cortex and medulla. These lesions were also detected by T2-weighted magnetic resonance imaging (MRI) as areas of increased signal intensity. Her brother demonstrated the same ultrasonographic results; cranial computed tomography disclosed low-density areas in the basal ganglia which were detected as hyperechoic lesions by ultrasonography. These findings suggest that ultrasonography is useful in detecting early intracranial lesions in Leigh disease.
T Yamagata; S Yano; I Okabe; M Miyao; M Y Momoi; M Yanagisawa; H Hirata; K Komatsu
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric neurology     Volume:  6     ISSN:  0887-8994     ISO Abbreviation:  Pediatr. Neurol.     Publication Date:    1990 Sep-Oct
Date Detail:
Created Date:  1991-01-03     Completed Date:  1991-01-03     Revised Date:  2006-05-23    
Medline Journal Info:
Nlm Unique ID:  8508183     Medline TA:  Pediatr Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  326-9     Citation Subset:  IM    
Department of Pediatrics, Jichi Medical School, Tochigi, Japan.
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MeSH Terms
Basal Ganglia / pathology,  ultrasonography
Cerebral Cortex / pathology,  ultrasonography
Leigh Disease / diagnosis*,  genetics,  ultrasonography
Magnetic Resonance Imaging
Medulla Oblongata / pathology,  ultrasonography

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