Document Detail

Ultrasonography of the brain, abdomen, and heart in neonates born to liver or renal transplant recipient mothers.
MedLine Citation:
PMID:  23274331     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Pregnancies in graft recipients are associated with increased risk of a number of pathologies. The aim of the study was to analyze results of brain and abdominal ultrasonography and echocardiography (ECHO) in neonates born to liver (LTx) or renal recipients (RTx).
MATERIAL/METHODS: The study group consisted of 82 neonates born to transplanted women (46 neonates of liver recipients and 36 neonates of renal recipients), enrolled in a retrospective study. The control group consisted of 74 neonates from the general population. Sonographic examination of the brain was performed to check for the presence of intra-/periventricular hemorrhage (IVH/PVH) according to Papile, and periventricular leukomalacia (PVL).The results of abdominal ultrasonography and 2-dimensional echocardiography (ECHO) were compared between the groups. The immunosuppressive therapy used during pregnancy was also analyzed.
RESULTS: No significant differences were observed between the frequency of IVH in LTx and RTx groups and LTx, RTx, and control groups. Abdominal ultrasonography revealed 1 case of suprarenal hemorrhage, 1 case of cystic kidney, and 3 cases of pyelocalyceal system dilatation in the study group. There were no abnormalities in the echocardiography in 97.8% of children born to mothers after LTx and in 94.4% after RTx. There were significant differences in the immunosuppressive therapy between the pregnant women after LTx and RTx.
CONCLUSIONS: The risk was not increased in intra-/periventricular hemorrhage and congenital abnormalities of the gastrointestinal tract and heart in neonates of mothers after organ transplantation, regardless of the immunotherapy used, and risk was similar to that of the general population.
Bożena Kociszewska-Najman; Bronisława Pietrzak; Joanna Schreiber-Zamora; Beata Borek-Dzięcioł; Katarzyna Bobrowska; Beata Kucińska; Zoulikha Jabiry-Zieniewicz; Robert Samaha; Agnieszka Biejat; Bożena Werner; Mirosław Wielgos
Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Annals of transplantation : quarterly of the Polish Transplantation Society     Volume:  17     ISSN:  2329-0358     ISO Abbreviation:  Ann. Transplant.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-31     Completed Date:  2013-05-28     Revised Date:  2013-06-17    
Medline Journal Info:
Nlm Unique ID:  9802544     Medline TA:  Ann Transplant     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  113-9     Citation Subset:  IM    
Division of Neonatology, 1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland.
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MeSH Terms
Abdomen / ultrasonography
Case-Control Studies
Congenital Abnormalities / etiology,  ultrasonography*
Digestive System Abnormalities / etiology,  ultrasonography
Heart Defects, Congenital / etiology,  ultrasonography
Immunosuppressive Agents / adverse effects
Infant, Newborn
Intracranial Hemorrhages / etiology,  ultrasonography*
Kidney Transplantation* / immunology
Leukomalacia, Periventricular / etiology,  ultrasonography*
Liver Transplantation* / immunology
Prenatal Exposure Delayed Effects / etiology,  ultrasonography*
Retrospective Studies
Urogenital Abnormalities / etiology,  ultrasonography
Reg. No./Substance:
0/Immunosuppressive Agents

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