| Ultrasonographic monitoring of response to therapy in polymyalgia rheumatica. | |
| | |
MedLine Citation:
|
PMID: 19773289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To assess the responsiveness of ultrasound (US) inflammatory findings in the shoulder and hip of patients with polymyalgia rheumatica (PMR) who started treatment with corticosteroids. METHODS: Fifty-three patients with active PMR who started treatment with prednisone in six Spanish centres were prospectively studied. The patients underwent clinical, laboratory and US assessment at baseline, 4 and 12 weeks. The US investigation consisted of detection and quantification of inflammatory findings in the shoulder and hip. The responsiveness of clinical, laboratory and US parameters was tested by the standardised response mean. Intraobserver and interobserver reliability between US investigators was assessed. RESULTS: At baseline, 34 patients (69%) had inflammation in at least one bilateral site. During the follow-up period, clinical, laboratory and US variables showed a parallel decrease. A significant decrease in US inflammatory parameters was found at week 4 (p<0.001). After 4 and 12 weeks of treatment with corticosteroids, US inflammatory findings showed similar or better sensitivity to change than clinical and laboratory markers of PMR activity. Intraobserver and interobserver intraclass correlation coefficients were 0.96 and 0.99, respectively (p<0.05). CONCLUSION: US may be a responsive additional tool in monitoring the response to corticosteroids in patients with PMR in daily practice and multicentre trials. |
| | |
Authors:
|
M Jim?nez-Palop; E Naredo; L Humbrado; J Medina; J Uson; F Francisco; M J Garc?a-Yebenes; J Garrido |
Related Documents
:
|
19711149 - Tacrolimus therapy for systemic lupus erythematosus without renal involvement: a prelim... 11549799 - Toxic epidermal necrolysis treated with intravenous high-dose immunoglobulins: our expe... 11380039 - Conventional treatment of crohn's disease: objectives and outcomes. 7740379 - Guidelines for the management of asthma in adults in south africa. part ii. acute asthm... 12125499 - Long-term effect of tcm decoctions in treatment of nephrotic syndrome. 19727839 - The use of low-dose cyclophosphamide followed by aza/mmf treatment in childhood lupus n... 8535669 - Renal function up to 16 years after conduit (refluxing or anti-reflux anastomosis) or c... 20666879 - Comparison of tretinoin 0.05% cream and 3% alcohol-based salicylic acid preparation in ... 17670709 - Does use of aprotinin decrease the incidence of stroke and neurological complications i... |
Publication Detail:
|
Type: Evaluation Studies; Journal Article; Multicenter Study Date: 2009-09-22 |
Journal Detail:
|
Title: Annals of the rheumatic diseases Volume: 69 ISSN: 1468-2060 ISO Abbreviation: Ann. Rheum. Dis. Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-04-23 Completed Date: 2010-06-15 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372355 Medline TA: Ann Rheum Dis Country: England |
Other Details:
|
Languages: eng Pagination: 879-82 Citation Subset: IM |
Affiliation:
|
Department of Rheumatology, Hospital Universitario Puerta de Hierro Majadahonda, Martin Iriarte 59, Madrid 28290, Spain. mjimenezp.hpth@salud.madrid.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Bursitis / ultrasonography Drug Monitoring / methods Female Follow-Up Studies Glucocorticoids / therapeutic use* Hip Joint / ultrasonography Humans Male Middle Aged Polymyalgia Rheumatica / drug therapy, ultrasonography* Prednisone / therapeutic use* Prospective Studies Shoulder Joint / ultrasonography Synovitis / ultrasonography Tenosynovitis / ultrasonography |
| Chemical | |
Reg. No./Substance:
|
0/Glucocorticoids; 53-03-2/Prednisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Tumour necrosis factor alpha blockade impairs dendritic cell survival and function in rheumatoid art...
Next Document: EULAR evidence-based recommendations for cardiovascular risk management in patients with rheumatoid ...