Document Detail


Ultrasonographic measures of cardiovascular disease risk in antiretroviral treatment-naive individuals with HIV infection.
MedLine Citation:
PMID:  23196938     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate associations between traditional cardiovascular disease (CVD) risk factors, inflammatory markers and markers of HIV disease activity with ultrasonographic measures of CVD risk in patients with HIV who are not receiving antiretroviral therapy (ART).
DESIGN: Cross-sectional, baseline evaluation of ART-naive HIV-infected individuals without known CVD or diabetes mellitus enrolled in a randomized ART treatment trial.
METHODS: Prior to ART initiation, carotid artery intima-media thickness (CIMT) and brachial artery flow-mediated dilation (FMD) were measured. Additional parameters included CD4 cell count, HIV viral load, body composition, lipoproteins and inflammatory markers. Associations with common CIMT, bifurcation CIMT, presence of carotid artery lesions and brachial artery FMD were evaluated.
RESULTS: The 331 enrolled individuals were a median (first-third quartile) of 36 (28-45) years old. Common and bifurcation CIMT values were higher and lesions more prevalent with older age (P < 0.001). FMD was lower with older age (P = 0.009). Those with a Framingham Risk Score of at least 6% per 10 years (N = 44) had higher common and bifurcation CIMT (P < 0.001), carotid lesion prevalence (P < 0.001) and lower FMD (P = 0.035). Independent associations with common CIMT were identified for increasing age, height, weight, small low-density lipoprotein (LDL) particles and black race; these were similar for bifurcation CIMT. Presence of carotid artery lesions was associated with increasing age, presence of metabolic syndrome, interleukin-6 and lower HIV-1 RNA.
CONCLUSION: In a contemporary cohort of ART-naive HIV-infected individuals, ultrasonographic measures of CVD risk were more strongly associated with traditional risk factors than CD4 cell counts, HIV replication or inflammatory markers.
Authors:
James H Stein; Todd T Brown; Heather J Ribaudo; Yun Chen; Mingzhu Yan; Elizabeth Lauer-Brodell; Grace A McComsey; Michael P Dubé; Robert L Murphy; Howard N Hodis; Judith S Currier
Related Documents :
24353708 - Hepatitis c genotype and associated risks factors of patients at university kebangsaan ...
23117698 - Prevalence of cardiovascular diseases in hiv-infected outpatients: results from a prosp...
16798718 - Prolonged latent schistosomiasis diagnosed 38 years after infestation in a hiv patient.
12688338 - Recent progress in the diagnosis and therapy for veno-occlusive disease of the liver.
22980338 - Knowledge, attitudes and practice of condom use among males aged (15-49) years in erbil...
24353708 - Hepatitis c genotype and associated risks factors of patients at university kebangsaan ...
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  AIDS (London, England)     Volume:  27     ISSN:  1473-5571     ISO Abbreviation:  AIDS     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-05-24     Completed Date:  2013-10-24     Revised Date:  2014-09-16    
Medline Journal Info:
Nlm Unique ID:  8710219     Medline TA:  AIDS     Country:  England    
Other Details:
Languages:  eng     Pagination:  929-37     Citation Subset:  IM; X    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Cardiovascular Diseases / diagnosis,  epidemiology*
Carotid Arteries / pathology*,  ultrasonography
Cross-Sectional Studies
Female
HIV Infections / complications*
Humans
Male
Middle Aged
Risk Assessment
Grant Support
ID/Acronym/Agency:
AI 068636/AI/NIAID NIH HHS; AI068634/AI/NIAID NIH HHS; AI56933/AI/NIAID NIH HHS; AI69471/AI/NIAID NIH HHS; HL095126/HL/NHLBI NIH HHS; HL095132/HL/NHLBI NIH HHS; K24 AI056933/AI/NIAID NIH HHS; R01 HL095126/HL/NHLBI NIH HHS; R01 HL095132/HL/NHLBI NIH HHS; U01 AI068634/AI/NIAID NIH HHS; U01 AI068636/AI/NIAID NIH HHS; U01 AI069471/AI/NIAID NIH HHS; U01AI068636/AI/NIAID NIH HHS; UM1 AI068634/AI/NIAID NIH HHS; UM1 AI068636/AI/NIAID NIH HHS; UM1 AI106701/AI/NIAID NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Risk of Kaposi sarcoma during the first months on combination antiretroviral therapy.
Next Document:  Interferon stimulated genes are associated with peginterferon plus ribavirin treatment response rega...