| Ultrasonographic hand features in systemic sclerosis and correlates with clinical, biological and radiographic findings. | |
| | |
MedLine Citation:
|
PMID: 22422556 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: To investigate ultrasonographic hand features in systemic sclerosis (SSc) patients and their relationships with clinical, biological and radiographic data. METHODS: 52 consecutive SSc patients were included in a cross-sectional observational study together with 24 patients with rheumatoid arthritis, enrolled as controls. All patients underwent clinical examination including tender joint and swollen joint counts, measurement of disability indices and hand/ wrist x-ray. Ultrasonography (US), performed on hand and wrist joints, aimed at the detection of synovitis, tenosynovitis and calcinosis. RESULTS: Synovitis and tenosynovitis were more frequently detected with US in SSc patients (46% and 27% respectively) than with clinical examination (15% and 6%, respectively) (p<0.01 for both comparisons). Synovitis was mildly inflammatory (Doppler grade 1) in 57% of SSc patients, and tenosynovitis was either inflammatory or fibrotic. Calcifications were observed with US and X-ray in 40% and 36% of SSc-patients, respectively (p=0.8). As compared to RA, US features specific to SSc were "sclerosing" tenosynovitis (p<0.01) and soft-tissue calcifications (p=0.01). CONCLUSION: Our study confirms that articular involvement in SSc is under-estimated by a single clinical examination. It is characterized by mild inflammatory changes and specific findings are sclerotic US aspect together with calcinosis. Further prospective studies are warranted to evaluate the predictive value of these findings and determine whether they should be considered for adapting therapeutic strategy. © 2012 by the American College of Rheumatology. |
| | |
Authors:
|
Muriel Elhai; Henri Guerini; Ramin Bazeli; Jerôme Avouac; Véronique Freire; Jean-Luc Drapé; André Kahan; Yannick Allanore |
Related Documents
:
|
15592726 - Orofacial apraxia in corticobasal degeneration, progressive supranuclear palsy, multipl... 15545016 - Studies on homocysteine and dehydroepiandrosterone sulphate plasma levels in alzheimer'... 18199096 - High prevalence of ascorbate deficiency in an australian peritoneal dialysis population. 12429196 - Increased red blood cell polyamines in als and parkinson's disease. 21755056 - Effluent markers related to epithelial mesenchymal transition with adjusted values for ... 18597156 - Elevated urinary nitrite and citrulline levels in patients with rheumatoid arthritis. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-3-15 |
Journal Detail:
|
Title: Arthritis care & research Volume: - ISSN: 2151-4658 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-3-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101518086 Medline TA: Arthritis Care Res (Hoboken) Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 by the American College of Rheumatology. |
Affiliation:
|
Paris Descartes University, Sorbonne Paris Cité, Rheumatology A department, Cochin Hospital, APHP, Paris, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Structured three-dimensional co-culture of mesenchymal stem cells with meniscus cells promotes menis...
Next Document: Multielectron Redox Chemistry of a Neutral, NIR-Active, Indigo-Pillared Re(I) -Based Triangular Meta...