Document Detail

Ultrasonographic fetal spleen measurements in red blood cell-alloimmunized pregnancies.
MedLine Citation:
PMID:  8333436     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: This study was performed to evaluate the possible relationship between fetal spleen size and fetal hemoglobin levels and to assess the predictive value of ultrasonographically measured fetal spleen size as an estimate of the severity of fetal hemolytic anemia. STUDY DESIGN: Before 85 consecutive fetal blood samples in 28 red blood cell-alloimmunized pregnancies ultrasonographic fetal spleen measurements were performed. Results were compared with our own longitudinally derived reference ranges and were correlated with fetal hemoglobin deficit. RESULTS: A significant positive correlation was found between spleen perimeter and fetal hemoglobin deficit. The ultrasonographic finding of splenomegaly correctly predicted severe fetal anemia (hemoglobin deficit > 5 SD from normal mean) in 44 of 47 cases, a positive predictive value of 94%. At first transfusion all fetuses showing splenomegaly were severely anemic. CONCLUSION: Fetal spleen measurements may be a useful adjunct to ultrasonographic evaluation in the management of severe red blood cell-alloimmunized pregnancies.
D Oepkes; R H Meerman; F P Vandenbussche; I L van Kamp; F G Kok; H H Kanhai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  169     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-08-19     Completed Date:  1993-08-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  121-8     Citation Subset:  AIM; IM    
Department of Obstetrics, University Hospital Leiden, The Netherlands.
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MeSH Terms
Anemia / etiology,  ultrasonography
Blood Group Incompatibility / complications,  ultrasonography*
Erythrocytes / immunology
Fetal Diseases / etiology,  ultrasonography
Hemoglobins / metabolism
Hydrops Fetalis / ultrasonography
Isoantigens / immunology
Pregnancy Complications / ultrasonography*
Spleen / embryology*,  ultrasonography*
Ultrasonography, Prenatal*
Reg. No./Substance:
0/Hemoglobins; 0/Isoantigens

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