| Ultrasonographic evidence of phenotypic instability during hepatocarcinogenesis in N-nitrosomorpholine-treated rats. | |
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MedLine Citation:
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PMID: 12127056 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Carcinogen-induced hepatoma in immunocompetent animal models has shown a progress similar to the clinical course of human hepatoma. Ultrasonography (US) was used for consecutive evaluation of the phenotypic changes in Sprague-Dawley rats exposed for 8 weeks to N-nitrosomorpholine (NNM, 200 mg/L). Three distinctive US findings were ascites, coarseness (defined as small and heterogeneously widespread increased echogenecity), and nodularity (defined as a >0.6-cm-sized echogenic region and clearly showing a tumor-like mass). Abdominal ascites was observed in 5 of 26 rats at week 8 NNM posttreatment and the number of rats showing ascites gradually increased. Coarseness (22 of 26 rats) and nodularity (1 of 18) appeared at weeks 8 and 17 NNM posttreatment, respectively. The gross and histological findings indicated that coarseness and nodularity shown in US reflected fibrosis and hepatocellular carcinoma or cholangiofibroma, respectively. The computer-aided quantification of coarseness and nodularity showed that the regression-linked phenotypic instability was present in coarseness but not in nodularity. We conclude that the heterogeneity of preneoplasia in NNM-treated rats might be induced by phenotypic instability rather than random initiating events of preneoplastic lesion. |
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Authors:
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Jong-Young Oh; Jin-Sook Jeong; Yu-jin Kim; Kyoung-Jin Nam; Byung-Ho Park; Eun-Young Kwon; Young-Hoon Kim; Tae-Ho Hwang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Experimental and molecular pathology Volume: 73 ISSN: 0014-4800 ISO Abbreviation: Exp. Mol. Pathol. Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-07-19 Completed Date: 2002-08-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370711 Medline TA: Exp Mol Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 67-73 Citation Subset: IM |
Affiliation:
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Institute of Medical Science, Department of Radiology, Medical College of Dong-A University, Busan 602-714, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Ascites / complications, ultrasonography Carcinoma, Hepatocellular / chemically induced*, complications, ultrasonography* Disease Models, Animal Fibrosis / chemically induced, complications, ultrasonography Image Processing, Computer-Assisted Liver / drug effects, pathology, ultrasonography* Liver Neoplasms, Experimental / chemically induced*, complications, ultrasonography* Male Nitrosamines* Phenotype Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Nitrosamines; 59-89-2/N-nitrosomorpholine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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