| Ultrasonographic detection of testicular ischemia in a canine model using phospholipid coated microbubbles (MRX-115). | |
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MedLine Citation:
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PMID: 9315169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to determine if the sonographic contrast agent MRX-115 could improve the accuracy of Doppler ultrasonographic diagnosis of testicular ischemia. Testicular duplex ultrasonography was performed on six dogs before and after surgical ligation of the testicular artery, and before and after intravenous injection of MRX-115. Six radiologists blinded to experimental conditions rated the testicular blood flow. Receiver operating characteristics curves for conditions with and without administration of contrast agent were compared using Student's t-test for paired observations. Statistically significant differences were found both for the tests viewed individually (P = 0.003) and for the testes in comparison to the contralateral side (P = 0.0001). MRX-115 therefore is found to improve duplex sonographic evaluation of testicular ischemia. |
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Authors:
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C Metzger-Rose; E A Krupinski; W H Wright; M R Baker; T P McCreery; T R Barrette; E C Unger |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine Volume: 16 ISSN: 0278-4297 ISO Abbreviation: J Ultrasound Med Publication Date: 1997 May |
Date Detail:
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Created Date: 1997-10-23 Completed Date: 1997-10-23 Revised Date: 2008-05-30 |
Medline Journal Info:
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Nlm Unique ID: 8211547 Medline TA: J Ultrasound Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 317-24; quiz 325-6 Citation Subset: IM |
Affiliation:
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Department of Radiology, University of Arizona, Tucson 85724-5067, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Chi-Square Distribution Confidence Intervals Contrast Media / administration & dosage* Disease Models, Animal Dogs Fluorocarbons / administration & dosage, diagnostic use* Injections, Intravenous Ischemia / ultrasonography* Male Observer Variation ROC Curve Sensitivity and Specificity Testis / blood supply*, ultrasonography* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Fluorocarbons; 76-19-7/perflutren |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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