Document Detail

Ultrasonically nebulized distilled water prevents exogenous histamine hyperreactivity in Toxocara canis-infected mice.
MedLine Citation:
PMID:  15973507     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study examines the effect of ultrasonically nebulized distilled water inhalation on the systemic histamine hyperreactivity of Toxocara canis-infected mice. METHODS: Uninfected and T. canis-infected mice received an intravenous sublethal dose of histamine and lethality rates were documented. At 24 days post infection, infected mice received ultrasonically nebulized distilled water inhalation for 1 h. Twenty-four hours later histamine levels were determined in bronchoalveolar lavage fluid as well as histamine lethality and toluidine blue-stained mast cell number in the lung. RESULTS: T. canis-infected mice showed increased lethality after exposure to histamine in comparison to uninfected mice. Ultrasonically nebulized distilled water inhalation prevented histamine-induced lethality and reduced toluidine blue-stained mast cell numbers in the lung. CONCLUSIONS: The correlation between decreases in stained mast cells in the lung after ultrasonically nebulized distilled water inhalation and inhibition of histamine-induced lethality in these animals suggests participation of mast cells in the phenomenon and could be helpful in understanding the mechanisms of hyperreactivity during helminth parasite infections.
A Sá-Nunes; R M F Bolzoni; A I Medeiros; M C Jamur; C Oliver; M Dias Baruffi; L H Faccioli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Inflammation research : official journal of the European Histamine Research Society ... [et al.]     Volume:  54     ISSN:  1023-3830     ISO Abbreviation:  Inflamm. Res.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-23     Completed Date:  2005-12-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9508160     Medline TA:  Inflamm Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  243-8     Citation Subset:  IM    
Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, 14040-903, São Paulo, Brazil.
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MeSH Terms
Anaphylaxis / chemically induced,  prevention & control
Histamine / administration & dosage*,  pharmacology*
Hypersensitivity / complications,  prevention & control*
Lung / drug effects,  parasitology,  pathology
Mast Cells / cytology,  drug effects
Mice, Inbred BALB C
Nebulizers and Vaporizers*
Serotonin / pharmacology
Toxocara canis / physiology*
Toxocariasis / complications*,  parasitology
Water / administration & dosage*,  chemistry
Reg. No./Substance:
50-67-9/Serotonin; 51-45-6/Histamine; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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