Document Detail


Ultrasonic resection of neuroblastomas. Long-term local tumor control.
MedLine Citation:
PMID:  7632154     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the effectiveness of ultrasonic aspiration in achieving local tumor control of bulky neutroblastomas that are considered unresectable by conventional means. DESIGN: A retrospective review of 12 patients undergoing ultrasonic aspiration as part of multimodal treatment protocols. SETTING: A pediatric oncology referral center. PATIENTS: Twelve children with large neuroblastomas located in the abdomen (n = 5), chest (n = 5), and neck (n = 2). Follow-up was 1.5 to 7.5 years. INTERVENTIONS: Ultrasonic aspiration of the tumor was primary therapy (n = 7) or followed initial chemotherapy (n = 5). All patients underwent subsequent chemotherapy or autologous bone marrow transplantation. MAIN OUTCOME MEASURES: The incidences of residual disease and local recurrence were examined. RESULTS: Tumor-related symptoms were effectively relieved in all 12 patients. Recurrent local disease led to death in two. One patient died of distant metastases. CONCLUSIONS: Ultrasonic aspiration minimized blood loss and did not cause damage to adjacent organs. It provided nearly complete tumor resection, enhanced the effectiveness of chemotherapy protocols, and decreased the need for supportive care. Ultrasonic aspiration is a safe and effective method for obtaining local control of large neuroblastomas.
Authors:
H Applebaum; L E Feinfeld
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of surgery (Chicago, Ill. : 1960)     Volume:  130     ISSN:  0004-0010     ISO Abbreviation:  Arch Surg     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-09-07     Completed Date:  1995-09-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9716528     Medline TA:  Arch Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  905-8     Citation Subset:  AIM; IM    
Affiliation:
Division of Pediatric Surgery, Kaiser Permanente Medical Center, Los Angeles, Calif., USA.
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MeSH Terms
Descriptor/Qualifier:
Abdominal Neoplasms / therapy*
Child
Child, Preschool
Follow-Up Studies
Head and Neck Neoplasms / therapy*
Humans
Infant
Infant, Newborn
Neoplasm Recurrence, Local / therapy*
Neoplasm, Residual
Neuroblastoma / therapy*
Retrospective Studies
Suction / methods*
Treatment Outcome
Ultrasonography, Interventional / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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