| Ultrasonic differentiation of normal versus malignant breast epithelial cells in monolayer cultures. | |
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MedLine Citation:
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PMID: 21110531 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Normal and malignant mammary epithelial cells were studied using laboratory measurements, wavelet analysis, and numerical simulations of monolayer cell cultures to determine whether microscopic breast cancer can be detected in vitro with high-frequency ultrasound. Pulse-echo waveforms were acquired by immersing a broadband, unfocused 50-MHz transducer in the growth media of cell culture well plates and collecting the first reflection from the well bottoms. The simulations included a multilayer pulse-reflection model and a model of two-dimensional arrays of spherical cells and nuclei. The results show that normal and malignant cells produce time-domain signals and spectral features that are significantly different. |
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Authors:
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Timothy E Doyle; Jeffrey B Goodrich; Brady J Ambrose; Hemang Patel; Soonjo Kwon; Lee H Pearson |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The Journal of the Acoustical Society of America Volume: 128 ISSN: 1520-8524 ISO Abbreviation: J. Acoust. Soc. Am. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-29 Completed Date: 2011-03-17 Revised Date: 2012-05-29 |
Medline Journal Info:
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Nlm Unique ID: 7503051 Medline TA: J Acoust Soc Am Country: United States |
Other Details:
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Languages: eng Pagination: EL229-35 Citation Subset: IM |
Affiliation:
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Department of Physics, Utah State University, Logan, Utah 84322, USA. tim.doyle@usu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Breast Neoplasms
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pathology,
ultrasonography* Cell Culture Techniques Cell Line, Tumor Epithelial Cells / pathology, ultrasonography* Female Humans Ultrasonics / instrumentation, methods* Wavelet Analysis* |
| Grant Support | |
ID/Acronym/Agency:
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5R21CA131798-02/CA/NCI NIH HHS; R21 CA131798/CA/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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