Document Detail

Ultrasonic characterization of in vitro osteoarthritic articular cartilage with validation by confocal microscopy.
MedLine Citation:
PMID:  9140179     Owner:  NLM     Status:  MEDLINE    
The majority of adults over the age of 65 y develop osteoarthritis (OA), a joint disease characterized by degeneration of articular cartilage and subchondral sclerosis. Early in the disease, the articular cartilage surface begins to change histologically from a smooth to a rough or fibrillated appearance. A prerequisite for any chondroprotective pharmacological intervention is detection of OA in its preclinical phase. Current diagnostic imaging modalities, such as radiographs or (nuclear) magnetic resonance imaging, either cannot directly image the cartilage surface or lack sufficient resolution to detect surface fibrillations. We have developed an ultrasonic technique that can be used to characterize these surface fibrillations directly. We present our in vitro results with validation by laser-based confocal microscopic imaging.
E H Chiang; T J Laing; C R Meyer; J L Boes; J M Rubin; R S Adler
Related Documents :
3740979 - New methods in arthroscopy: preliminary investigations.
19530259 - Characterization of engineered tissue construct mechanical function by magnetic resonan...
12060469 - Utilization of a high-resolution digital imaging system for the objective and quantitat...
9805189 - Clinical, radiographic and echocardiographic findings in a patient with ochronosis.
17418219 - A comparison of the influence of global functional loads vs. local contact anatomy on a...
22798989 - Current concepts in f18 fdg pet/ct-based radiation therapy planning for lung cancer.
11248429 - Magnetic resonance lipid signals in rat brain after experimental stroke correlate with ...
15952689 - State-of-the-art imaging with 64-channel multidetector ct angiography.
11380759 - Serum carotenoids and cerebral white matter lesions: the rotterdam scan study.
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  23     ISSN:  0301-5629     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  1997  
Date Detail:
Created Date:  1997-07-10     Completed Date:  1997-07-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  205-13     Citation Subset:  IM    
Department of Radiology, University of Michigan Medical Center, Ann Arbor 48109-0030, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cartilage, Articular / pathology,  ultrasonography*
Image Processing, Computer-Assisted
Microscopy, Confocal
Osteoarthritis / pathology,  ultrasonography*
Phantoms, Imaging

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Characterisation of atherosclerotic plaque by spectral analysis of intravascular ultrasound: an in v...
Next Document:  Parametric (integrated backscatter and attenuation) images constructed using backscattered radio fre...