Document Detail


Ultrasonic characterization of in vitro osteoarthritic articular cartilage with validation by confocal microscopy.
MedLine Citation:
PMID:  9140179     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The majority of adults over the age of 65 y develop osteoarthritis (OA), a joint disease characterized by degeneration of articular cartilage and subchondral sclerosis. Early in the disease, the articular cartilage surface begins to change histologically from a smooth to a rough or fibrillated appearance. A prerequisite for any chondroprotective pharmacological intervention is detection of OA in its preclinical phase. Current diagnostic imaging modalities, such as radiographs or (nuclear) magnetic resonance imaging, either cannot directly image the cartilage surface or lack sufficient resolution to detect surface fibrillations. We have developed an ultrasonic technique that can be used to characterize these surface fibrillations directly. We present our in vitro results with validation by laser-based confocal microscopic imaging.
Authors:
E H Chiang; T J Laing; C R Meyer; J L Boes; J M Rubin; R S Adler
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  23     ISSN:  0301-5629     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  1997  
Date Detail:
Created Date:  1997-07-10     Completed Date:  1997-07-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  205-13     Citation Subset:  IM    
Affiliation:
Department of Radiology, University of Michigan Medical Center, Ann Arbor 48109-0030, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cartilage, Articular / pathology,  ultrasonography*
Humans
Image Processing, Computer-Assisted
Microscopy, Confocal
Osteoarthritis / pathology,  ultrasonography*
Phantoms, Imaging

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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