Document Detail

Ultrasonic characterization (integrated backscatter) of myocardial tissue in patients with autosomal dominant polycystic kidney disease.
MedLine Citation:
PMID:  20090371     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study changes in myocardial wall texture in autosomal dominant polycystic kidney disease (ADPKD) patients by ultrasonic integrated backscatter (IBS) analysis.
METHODS: Hypertensive and normotensive ADPKD patients, essential hypertension (EHP) patients and healthy volunteers were included in the study. All the subjects underwent conventional echocardiography and ultrasonic IBS of the myocardial wall. Both the calibrated IBS (C-IBS) and the systolic-diastolic cyclical variations in IBS (CV-IBS) were evaluated.
RESULTS: Mean C-IBS in hypertensive ADPKD patients was significantly higher than that in EHP patients and normotensive ADPKD patients. Mean C-IBS in normotensive ADPKD patients was significantly higher than that in healthy subjects. Mean CV-IBS in hypertensive ADPKD patients was significantly lower than that in EHP patients and normotensive ADPKD patients. Mean CV-IBS in normotensive ADPKD patients was significantly lower than that in healthy subjects. Multivariate analysis showed that the mean C-IBS was positively related to the systolic and diastolic blood pressure (SBP, DBP) and left ventricular mass index (LVMI); mean CV-IBS was positively correlated with contractile performance and transmitral E/A ratio and inversely correlated with SBP, DBP and LVMI.
CONCLUSIONS: ADPKD patients experienced myocardial interstitial collagen deposition and impairment to myocardial contractile performance, which were both aggravated by hypertension. IBS seems to be a useful tool for the assessment of myocardial changes in ADPKD patients.
Xiucai Jin; Shu Rong; Changlin Mei; Jiabin Chen; Chaoyang Ye; Xiaoyu Chen
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-01-20
Journal Detail:
Title:  Nephron. Clinical practice     Volume:  114     ISSN:  1660-2110     ISO Abbreviation:  Nephron Clin Pract     Publication Date:  2010  
Date Detail:
Created Date:  2010-04-16     Completed Date:  2010-12-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101159763     Medline TA:  Nephron Clin Pract     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  c288-94     Citation Subset:  IM    
Copyright Information:
Copyright 2010 S. Karger AG, Basel.
Department of Ultrasound, Nephrology Institute of CPLA, Changzheng Hospital, Second Military Medical University, Shanghai, China.
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MeSH Terms
Hypertension / complications,  pathology,  ultrasonography
Middle Aged
Myocardium / pathology*
Polycystic Kidney, Autosomal Dominant / complications*,  pathology,  ultrasonography*
Ultrasonography, Interventional / methods*

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