Document Detail


Ultrasmall implantable composite microelectrodes with bioactive surfaces for chronic neural interfaces.
MedLine Citation:
PMID:  23142839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Implantable neural microelectrodes that can record extracellular biopotentials from small, targeted groups of neurons are critical for neuroscience research and emerging clinical applications including brain-controlled prosthetic devices. The crucial material-dependent problem is developing microelectrodes that record neural activity from the same neurons for years with high fidelity and reliability. Here, we report the development of an integrated composite electrode consisting of a carbon-fibre core, a poly(p-xylylene)-based thin-film coating that acts as a dielectric barrier and that is functionalized to control intrinsic biological processes, and a poly(thiophene)-based recording pad. The resulting implants are an order of magnitude smaller than traditional recording electrodes, and more mechanically compliant with brain tissue. They were found to elicit much reduced chronic reactive tissue responses and enabled single-neuron recording in acute and early chronic experiments in rats. This technology, taking advantage of new composites, makes possible highly selective and stealthy neural interface devices towards realizing long-lasting implants.
Authors:
Takashi D Yoshida Kozai; Nicholas B Langhals; Paras R Patel; Xiaopei Deng; Huanan Zhang; Karen L Smith; Joerg Lahann; Nicholas A Kotov; Daryl R Kipke
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-11-11
Journal Detail:
Title:  Nature materials     Volume:  11     ISSN:  1476-1122     ISO Abbreviation:  Nat Mater     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-23     Completed Date:  2013-02-11     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101155473     Medline TA:  Nat Mater     Country:  England    
Other Details:
Languages:  eng     Pagination:  1065-73     Citation Subset:  IM    
Affiliation:
Neural Engineering Lab, Department of Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA. tkozai@umich.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbon / chemistry
Electrodes, Implanted*
Microelectrodes*
Rats
Synaptic Potentials*
Grant Support
ID/Acronym/Agency:
1RC1NS068396-0110/NS/NINDS NIH HHS; P41 EB002030/EB/NIBIB NIH HHS; P41 EB002030/EB/NIBIB NIH HHS; RC1 NS068396/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/carbon fiber; 7440-44-0/Carbon
Comments/Corrections

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