| Ultrasmall Superparamagnetic Particles of Iron Oxide in Patients with Acute Myocardial Infarction: Early Clinical Experience. | |
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MedLine Citation:
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PMID: 22875883 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: -Inflammation following acute myocardial infarction has detrimental effects on reperfusion, myocardial remodelling and ventricular function. Magnetic resonance imaging using ultrasmall superparamagnetic particles of iron oxide (USPIO) can detect cellular inflammation in tissues, and we therefore explored its role in acute myocardial infarction in humans. METHODS AND RESULTS: -Sixteen patients within five days of ST-segment elevation myocardial infarction underwent 3 sequential magnetic resonance scans at -1, 24 and 48 h following no infusion (controls; n=6) or intravenous infusion of USPIO (n=10; 4 mg/kg). T2*-weighted multi-gradient-echo sequences were acquired and R2* values calculated for specific regions of interest. In the control group, R2* remained constant in all tissues throughout all scans with excellent repeatability (bias of -0.208, s(-1), coefficient of repeatability of 26.96, s(-1); intra-class coefficient 0.989). Consistent with uptake by the reticuloendothelial system, R2* increased in the liver (84±49.5 to 319±70.0 s(-1); p<0.001) but was unchanged in skeletal muscle (54±8.4 to 67.0±9.5 s(-1); p>0.05) 24 hours after USPIO administration. In the myocardial infarct, R2* increased from 41.0±12.0 (baseline) to 155±45.0 (p<0.001) and 124±35.0 s(-1) (p<0.05) at 24 and 48 h respectively. A similar but lower magnitude response was seen in the remote myocardium from 39±3.2 to 80±14.9 (p<0.001) and 67.0±15.7 s(-1) (p<0.05) respectively. CONCLUSIONS: -Following acute myocardial infarction, USPIO uptake occurs with the infarcted and remote myocardium. This technique holds major promise as a potential method of assessing cellular myocardial inflammation and left ventricular remodelling that may have a range of applications in patients with myocardial infarction and other inflammatory cardiac conditions. Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01323296. |
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Authors:
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Shirjel R Alam; Anoop S V Shah; Jennifer Richards; Ninian N Lang; Gareth Barnes; Nikhil Joshi; Tom Macgillivray; Graham McKillop; Saeed Mirsadraee; John Payne; Keith A A Fox; Peter Henriksen; David E Newby; Scott I K Semple |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-8 |
Journal Detail:
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Title: Circulation. Cardiovascular imaging Volume: - ISSN: 1942-0080 ISO Abbreviation: Circ Cardiovasc Imaging Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101479935 Medline TA: Circ Cardiovasc Imaging Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1 Centre of Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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