Document Detail


Ultrasensitivity part III: cascades, bistable switches, and oscillators.
MedLine Citation:
PMID:  25456048     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Switch-like, ultrasensitive responses - responses that resemble those of cooperative enzymes but are not necessarily generated by cooperativity - are widespread in signal transduction. In the previous installments in this series, we reviewed several mechanisms for generating ultrasensitivity: zero-order ultrasensitivity; multistep ultrasensitivity; inhibitor ultrasensitivity; and positive feedback (or double negative feedback) loops. In this review, we focus on how ultrasensitive components can be important for the functioning of more complex signaling circuits. Ultrasensitivity can allow the effective transmission of signals down a signaling cascade, can contribute to the generation of bistability by positive feedback, and can promote the production of biochemical oscillations in negative feedback loops. This makes ultrasensitivity a key building block in systems biology and synthetic biology.
Authors:
James E Ferrell; Sang Hoon Ha
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Publication Detail:
Type:  REVIEW     Date:  2014-11-10
Journal Detail:
Title:  Trends in biochemical sciences     Volume:  39     ISSN:  0968-0004     ISO Abbreviation:  Trends Biochem. Sci.     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-12-2     Completed Date:  -     Revised Date:  2014-12-3    
Medline Journal Info:
Nlm Unique ID:  7610674     Medline TA:  Trends Biochem Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  612-618     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Ltd. All rights reserved.
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