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Ultrasensitive serum thyroglobulin measurement is useful for the follow-up of patients treated with total thyroidectomy without RAI ablation.
MedLine Citation:
PMID:  23939918     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
CONTEXT: Thyroglobulin (Tg) measurement is a major tool for the follow-up of differentiated thyroid cancer (DTC) patients, however, in patients who do not undergo radioactive iodine (RAI) ablation, normal ultrasensitive Tg levels measured under levothyroxine treatment (usTg/LT4) are not well defined.
OBJECTIVE-DESIGN: This single centre retrospective study assessed usTg/LT4 level in 86 consecutive patients treated with total thyroidectomy without RAI ablation for low risk DTC (n=77) or for tumors of uncertain malignant potential (TUMP) (n=9). Results: DTC were classified as pT1, pT2 and pT3 in 75, 1 and 1 case, respectively and pN0, pN1 and pNx in 40, 6 and 31, respectively. Following surgery, 10 patients had Tg antibodies (TgAb). Among those without TgAb, the first usTg/LT4 determination obtained at a mean time of 9 months after surgery was ≤ 0.1 ng/mL in 62% of cases, ≤ 0.3 ng/mL in 82%, ≤ 1 ng/mL in 91% and ≤ 2 ng/mL in 96% of cases. After a median follow up of 2.5 years (range: 0.6-7.2 yr), one patient had persistent disease with an usTg/LT4 at 11 ng/mL and an abnormal neck ultrasonography and two patients had usTg/LT4 level greater than 2 ng/mL (3.9 and 4.9 ng/mL) with a normal neck ultrasonography. Within the first two years following total thyroidectomy without RAI ablation, usTg/LT4 level is ≤ 2 ng/mL in 96% of the cases.
CONCLUSION: After total thyroidectomy, sensitive serum Tg/LT4 level is ≤ 2 ng/mL in most patients and can be used for patient follow-up.
Authors:
Camila Nascimento; Isabelle Borget; Frederic Troalen; Abir Al Ghuzlan; Desiree Deandreis; Dana Hartl; Jean Lumbroso; Cecile N Chougnet; Eric Baudin; Martin Schlumberger; Sophie Leboulleux
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-8-12
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  -     ISSN:  1479-683X     ISO Abbreviation:  Eur. J. Endocrinol.     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
C Nascimento, Department of Nuclear Medicine and Endocrine Oncology, Institut Gustave Roussy, Villejuif, France.
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