| Ultrarapid high-dose course of prophylactic cranial irradiation in small-cell lung cancer: evaluation of late neurologic morbidity in 16 long-term survivors. | |
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MedLine Citation:
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PMID: 9499267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite the reduction in the incidence of brain metastases following prophylactic cranial irradiation (PCI) in patients with small-cell lung cancer (SCLC), the use of this modality is still controversial due to the lack of improvement in survival and the appearance of neurotoxicity in long-term survivors. Moreover, the optimum dose, fraction size, and timing are not known. From 1980 to 1988, 70 patients with limited stage SCLC underwent PCI after or during multimodality treatment of their primary tumor. Most of these patients (75.7%) received an unconventional ultrarapid high-dose course of 17 Gy in two fractions over 3 days. Long-term (range 60-138 months) survivors (n = 16) were invited to have a complete neurological evaluation including computed cranial tomography (CCT), 99mTc-HMPAO single photon emission computerized tomography (SPECT) scan, electroencephalography (EEG), magnetic resonance imaging (MRI), and neuropsychometry. Delayed neurologic complications or psychometric impairment was observed in 46% of patients. One or more abnormalities were detected by CCT in all patients, and the presence of neurologic complications seemed to correlate with periventricular and subcortical white matter changes. A strong correlation was found between CCT and SPECT periventricular white matter changes. Although the incidence of late neurologic toxicity following this rapid course of irradiation was high, clinical findings were less severe than expected, and all the patients were capable of self-care. |
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Authors:
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L Tomio; M Romano; G Zanchin; C Carollo; P Amista; L Loreggian; G Saladini; F Berti; M Pignataro; A Paccagnella; A Favaretto; F Rea; F Calzavara |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of clinical oncology Volume: 21 ISSN: 0277-3732 ISO Abbreviation: Am. J. Clin. Oncol. Publication Date: 1998 Feb |
Date Detail:
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Created Date: 1998-03-06 Completed Date: 1998-03-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8207754 Medline TA: Am J Clin Oncol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 84-90 Citation Subset: IM |
Affiliation:
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Department of Radiotherapy, University of Padua, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Brain / radiation effects, radionuclide imaging Brain Neoplasms / prevention & control*, secondary Carcinoma, Small Cell / secondary*, therapy* Combined Modality Therapy Cranial Irradiation* Electroencephalography Female Humans Lung Neoplasms / pathology*, therapy* Male Middle Aged Radiotherapy Dosage Survival Analysis Tomography, Emission-Computed, Single-Photon Tomography, X-Ray Computed |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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