| Ultraporous β-Tricalcium Phosphate Alone or Combined with Bone Marrow Aspirate for Benign Cavitary Lesions: Comparison in a Prospective Randomized Clinical Trial. | |
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MedLine Citation:
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PMID: 23324964 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Ultraporous β-tricalcium phosphate (TCP) synthetic graft material (Vitoss; Orthovita) persists for a year or longer in some cases. In this study, we prospectively examined healing of cavitary defects filled with TCP versus TCP and bone marrow aspirate (TCP/BM) with the hypothesis that bone-marrow aspirate speeds incorporation of bone graft substitute. METHODS: Fifty-five patients with a benign bone lesion undergoing surgical curettage were randomized to receive TCP (N = 26; mean duration of follow-up [and standard deviation], 20.2 ± 7.2 months) or TCP/BM (N = 29; mean duration of follow-up, 18.0 ± 7.7 months). There were no significant differences between the groups with regard to demographic or defect parameters. Clinical and radiographic evaluations were done at 1.5, three, six, twelve, eighteen, and twenty-four months, and computed tomography [CT] scans were performed at twelve months. An independent radiographic review was done to evaluate six parameters. RESULTS: There was a significant (p < 0.001) increase in trabeculation through the defect and graft resorption with decreases in the persistence of the graft in both soft tissue and the defect as well as a decreased radiolucent rim around the graft over time. No significant differences were observed between the TCP and TCP/BM groups in terms of any radiographic parameter. No complications related to the graft material or BM were identified. CONCLUSIONS: While significant improvements in radiographic parameters were observed in both TCP groups over two years of follow-up, the addition of BM was not found to provide any significant benefit. Results should not be extrapolated to other bone graft substitutes used for this purpose. LEVEL OF EVIDENCE: Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence. |
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Authors:
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Timothy A Damron; Jennifer Lisle; Tina Craig; Michael Wade; Walter Silbert; Hal Cohen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of bone and joint surgery. American volume Volume: 95 ISSN: 1535-1386 ISO Abbreviation: J Bone Joint Surg Am Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0014030 Medline TA: J Bone Joint Surg Am Country: United States |
Other Details:
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Languages: eng Pagination: 158-66 Citation Subset: AIM; IM |
Affiliation:
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Department of Orthopedic Surgery, SUNY Upstate Medical University, 6620 Fly Road, East Syracuse, NY 13057. E-mail address for T.A. Damron: damront@upstate.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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