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Ultrahigh-pressure liquid chromatography: fundamental aspects of compression and decompression heating.
MedLine Citation:
PMID:  18334091     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Ultrahigh-pressure liquid chromatography is an emerging technique for carrying out rapid and highly efficient separations. Unfortunately, one of the simplifying assumptions made in conventional high-performance liquid chromatography, incompressibility of the mobile phase, is not valid when higher and higher pressures are used. Rather, both compression and decompression of the eluent must be considered in terms of both heating and changes in the solvent's structure. The first of these problems, eluent heating during the compression and decompression cycles, which occurs in the pump and column, respectively, are considered in terms of a combined first principle-empirical approach that is solved (i.e., an analytic solution obtained from the resulting integral equation) using 0.01 Bar pressure steps. The approach is used to estimate compression and decompression heating for methanol and water.
R K Gilpin; W Zhou
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of chromatographic science     Volume:  46     ISSN:  0021-9665     ISO Abbreviation:  J Chromatogr Sci     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-12     Completed Date:  2008-05-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0173225     Medline TA:  J Chromatogr Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  248-53     Citation Subset:  -    
Brehm Research Laboratory, University Park, Wright State University, Fairborn, OH 45324-2031, USA.
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