Document Detail

Ultrafine particles in alveolar macrophages from normal children.
MedLine Citation:
PMID:  11713355     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Increased ambient levels of particulate matter <10 microm (PM(10)) from fossil fuel combustion are associated with an increased prevalence of respiratory symptoms in children. However, it is unknown whether, and to what extent, pollutant particles penetrate the paediatric lower airway. The capacity of alveolar macrophages (AM) to phagocytose inhaled material was used to directly assess exposure of normal children to particles. METHODS: AM from 22 children aged 3 months to 16 years with no respiratory symptoms were obtained by non-bronchoscopic bronchoalveolar lavage prior to elective surgery. In each child the size and composition of environmental particles within single sections from 100 separate AM was determined by electron microscopy and microanalysis. RESULTS: Single and clusters of particles were seen in AM from all children. The percentage of particle-containing AM ranged from 1% to 16% per child. Particles consisted of a carbonaceous core and all were ultrafine (<0.1 microm). Other elements such as metals and silicon were not detected. The percentage of particle-containing AM did not change with age, but was increased in children whose parents lived on a main road compared with those living on a quiet residential road (median 10% v 3%, p = 0.014). CONCLUSIONS: All children had AM containing ultrafine carbonaceous particles. The predominant source of these particles is most likely to be from the combustion of fossil fuels.
H J Bunn; D Dinsdale; T Smith; J Grigg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thorax     Volume:  56     ISSN:  0040-6376     ISO Abbreviation:  Thorax     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-11-19     Completed Date:  2001-12-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  England    
Other Details:
Languages:  eng     Pagination:  932-4     Citation Subset:  IM    
Leicester Children's Asthma Centre, Institute for Lung Health, University of Leicester, Leicester LE2 7LX, UK.
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MeSH Terms
Air Pollutants / analysis*
Bronchoalveolar Lavage Fluid / cytology
Carbon / analysis*
Child, Preschool
Confidence Intervals
Electron Probe Microanalysis
Foreign Bodies*
Macrophages, Alveolar*
Microscopy, Electron
Particle Size
Statistics, Nonparametric
Urban Health
Reg. No./Substance:
0/Air Pollutants; 7440-44-0/Carbon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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