Document Detail


Ultrafine particle-lung interactions: does size matter?
MedLine Citation:
PMID:  16551218     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epidemiological studies continue to indicate associations between exposure to increased concentrations of ambient fine and ultrafine particles and adverse health effects in susceptible individuals. The ultrafine particle fraction in the ambient atmosphere seems to play a specific role. Yet, the dosimetry (including deposition patterns in the respiratory tract and, particularly, the biokinetic fate of ultrafine particles) is not fully understood. In contrast to fine particles, inhaled ultrafine particles seem to follow different routes in the organism. Cardiovascular effects observed in epidemiological studies triggered the discussion on enhanced translocation of ultrafine particles from the respiratory epithelium towards circulation and subsequent target organs, such as heart, liver, and brain, eventually causing adverse effects on cardiac function and blood coagulation, as well as on functions of the central nervous system. Current knowledge on systemic translocation of ultrafine particles in humans and animal models is reviewed. Additionally, an estimate of accumulating particle numbers in secondary target organs during chronic exposure is extrapolated from long-term translocation data obtained from rats. Toxicological studies aim to provide the biological plausibility of health effects of ultrafine particles and to identify cascades of mechanisms that are causal for the gradual transition from the physiological status towards pathophysiologcal alterations and eventually chronic disease. Considering the interaction between insoluble ultrafine particles and biological systems (such as body fluids, proteins, and cells), there still are gaps in the current knowledge on how ultrafine particles may cause adverse reactions. This paper reviews the current concept of interactions between insoluble ultrafine particles and biological systems.
Authors:
Wolfgang G Kreyling; Manuela Semmler-Behnke; Winfried Möller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine     Volume:  19     ISSN:  0894-2684     ISO Abbreviation:  J Aerosol Med     Publication Date:  2006  
Date Detail:
Created Date:  2006-03-22     Completed Date:  2006-05-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8809251     Medline TA:  J Aerosol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  74-83     Citation Subset:  T    
Affiliation:
Institute of Inhalation Biology, GSF-Focus: Aerosols and Health, GSF-National Research Center for Environment and Health, Neuherberg/Munich, Germany. Kreyling@gsf.de
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MeSH Terms
Descriptor/Qualifier:
Aerosols
Air Pollutants / pharmacokinetics*
Animals
Bronchi / metabolism
Humans
Inhalation Exposure / adverse effects*
Lung / metabolism*
Particle Size*
Tissue Distribution
Trachea / metabolism
Chemical
Reg. No./Substance:
0/Aerosols; 0/Air Pollutants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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