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Ultrafast sequencing of oligodeoxyribonucleotides by FAB-mass spectrometry.
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MedLine Citation:
PMID:  7133994     Owner:  NLM     Status:  MEDLINE    
A fully instrumental method is described for the bidirectional sequencing of oligodeoxyribonucleotides. The method makes use of the negative ion fragmentation patterns of fast atom bombardment mass spectrometry. It is less time consuming than any other sequencing procedure known to date. Since one sequencing run takes as little as one hour, this new method is anticipated to cut down considerably the time required for the controlled synthesis of oligodeoxyribonucleotides of (currently) up to ten nucleotide units in length.
L Grotjahn; R Frank; H Blöcker
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nucleic acids research     Volume:  10     ISSN:  0305-1048     ISO Abbreviation:  Nucleic Acids Res.     Publication Date:  1982 Aug 
Date Detail:
Created Date:  1982-12-16     Completed Date:  1982-12-16     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0411011     Medline TA:  Nucleic Acids Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  4671-8     Citation Subset:  IM    
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MeSH Terms
Base Sequence
Mass Spectrometry / methods
Reg. No./Substance:
0/Oligodeoxyribonucleotides; 0/Oligonucleotides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Nucleic Acids Res
ISSN: 0305-1048
ISSN: 1362-4962
Article Information
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Print publication date: Day: 11 Month: 8 Year: 1982
Volume: 10 Issue: 15
First Page: 4671 Last Page: 4678
ID: 321120
PubMed Id: 7133994

Ultrafast sequencing of oligodeoxyribonucleotides by FAB-mass spectrometry.
L Grotjahn
R Frank
H Bl?cker

Article Categories:
  • Research Article

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