Document Detail


Ultrafast Structural Dynamics of BlsA, a Photoreceptor from the Pathogenic Bacterium Acinetobacter baumannii.
MedLine Citation:
PMID:  24723998     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Acinetobacter baumannii is an important human pathogen that can form biofilms and persist under harsh environmental conditions. Biofilm formation and virulence are modulated by blue light, which is thought to be regulated by a BLUF protein, BlsA. To understand the molecular mechanism of light sensing, we have used steady-state and ultrafast vibrational spectroscopy to compare the photoactivation mechanism of BlsA to the BLUF photosensor AppA from Rhodobacter sphaeroides. Although similar photocycles are observed, vibrational data together with homology modeling identify significant differences in the β5 strand in BlsA caused by photoactivation, which are proposed to be directly linked to downstream signaling.
Authors:
Richard Brust; Allison Haigney; Andras Lukacs; Agnieszka Gil; Shahrier Hossain; Kiri Addison; Cheng-Tsung Lai; Michael Towrie; Gregory M Greetham; Ian P Clark; Boris Illarionov; Adelbert Bacher; Ryu-Ryun Kim; Markus Fischer; Carlos Simmerling; Stephen R Meech; Peter J Tonge
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-12-06
Journal Detail:
Title:  The journal of physical chemistry letters     Volume:  5     ISSN:  1948-7185     ISO Abbreviation:  J Phys Chem Lett     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-4-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101526034     Medline TA:  J Phys Chem Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  220-224     Citation Subset:  -    
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