| Ultracytochemical localization of glucose-6-phosphatase in Chang rat hepatoma in vivo and in vitro. | |
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MedLine Citation:
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PMID: 192899 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The standard lead precipitation method was used for ultracytochemical localization of glucose-6-phosphatase (G-6-Pase) in the in vivo and in vitro forms of the Chang rat hepatoma and in the normal adult rat liver. Reaction product was visualized as very fine particulate within the cisternae of the nuclear envelope and endoplasmic reticulum. Cytochemically, the amount of the G-6-Pase reaction product in both forms of the tumor cells was obviously less than that in the normal hepatocytes. Apparently, the enzyme was not completely deleted from the hepatoma cells. The results supported some biochemical data of certain other hepatomas. The successful ultracytochemical localization of G-6-Pase in cultured hepatoma cells has not been reported previously. |
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Authors:
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P C Moller; M Yokoyama; J P Chang |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of the National Cancer Institute Volume: 58 ISSN: 0027-8874 ISO Abbreviation: J. Natl. Cancer Inst. Publication Date: 1977 May |
Date Detail:
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Created Date: 1977-06-22 Completed Date: 1977-06-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7503089 Medline TA: J Natl Cancer Inst Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1401-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinoma, Hepatocellular / enzymology*, ultrastructure Cells, Cultured Endoplasmic Reticulum / enzymology Glucose-6-Phosphatase / metabolism* Liver / enzymology Liver Neoplasms / enzymology*, ultrastructure Neoplasms, Experimental / enzymology, ultrastructure Nuclear Envelope / enzymology Rats |
| Chemical | |
Reg. No./Substance:
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EC 3.1.3.9/Glucose-6-Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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