Document Detail

Ultra-sensitive detection of adipocytokines with CMOS-compatible silicon nanowire arrays.
MedLine Citation:
PMID:  20644875     Owner:  NLM     Status:  MEDLINE    
Perfectly aligned arrays of single-crystalline silicon nanowires were fabricated using top-down CMOS-compatible techniques. We demonstrate that these nanowire devices are able to detect adipocytokines secreted by adipose cells with femtomolar sensitivity, high specificity, wide detection range, and ability for parallel monitoring. The nanowire sensors also provide a novel tool to reveal the poorly understood signaling mechanisms of these newly recognized signaling molecules, as well as their relevance in common diseases such as obesity and diabetes.
Tze-Sian Pui; Ajay Agarwal; Feng Ye; Zhi-Qiang Tou; Yinxi Huang; Peng Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-13
Journal Detail:
Title:  Nanoscale     Volume:  1     ISSN:  2040-3372     ISO Abbreviation:  Nanoscale     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2010-07-20     Completed Date:  2010-10-28     Revised Date:  2011-06-22    
Medline Journal Info:
Nlm Unique ID:  101525249     Medline TA:  Nanoscale     Country:  England    
Other Details:
Languages:  eng     Pagination:  159-63     Citation Subset:  IM    
Institute of Microelectronics, A*STAR (Agency for Science, Technology and Research), 11 Science Park Road, 117685 Singapore.
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MeSH Terms
Adipocytes / secretion
Adipokines / analysis*,  chemistry,  secretion
Biosensing Techniques / methods*
Cell Line
Limit of Detection
Microscopy, Electron, Transmission
Nanowires / chemistry*
Silicon / chemistry*
Reg. No./Substance:
0/Adipokines; 7440-21-3/Silicon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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