| Ultra high-field magnetic resonance imaging of a glaucoma microstent. | |
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MedLine Citation:
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PMID: 21780921 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Purpose: The aim of the present study was to use 7.1T magnetic resonance imaging (MRI) to determine the correct anatomical position of a non-metallic glaucoma microstent following implantation in rabbit eyes. Materials and Methods: In an in vitro experiment three microstents (made from silicone, polyurethane, and nickel titanium) were embedded in a standard vial filled with agar. In a second series of experiments a prefabricated polyurethane microstent connecting the anterior chamber with the suprachoroidal space (SCS) was implanted in rabbit eyes (n = 12). High-resolution images were acquired ex vivo (n = 6) and in vivo (n = 6) on an ultra high-field MRI unit using a 2-channel coil with four coil elements and T2-weighted turbo spin-echo sequences. Finally, the eyes were dissected and processed for histology. Results: Artifact-free MR imaging of silicone and polyurethane microstents was achieved in vitro, with slightly higher contrast for silicone stents. Image quality for the nickel titanium stent was greatly reduced due to artifacts. MRI examination of rabbit eyes ex vivo and in vivo following polyurethane microstent implantation presented no problems in terms of the size and placement of the coil. The sequences showed good image quality; the full length of the microstent was visualized in cross-section and longitudinal section, and correct anatomical placement was demonstrated from the anterior chamber into the SCS. These findings were verified by histology. Conclusions: The excellent image quality obtained with both of the non-metallic materials generates detailed information about microstent placement, including the surrounding tissues. High-resolution MRI can be used to monitor the anatomical position of a microstent after glaucoma surgery in animal experiments and is therefore a valuable tool for documenting experimental research findings ex vivo and in vivo. |
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Authors:
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Reto Allemann; Sönke Langner; Martin Witt; Wolfram Schmidt; Klaus-Peter Schmitz; Norbert Hosten; Rudolf Guthoff; Oliver Stachs |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current eye research Volume: 36 ISSN: 1460-2202 ISO Abbreviation: Curr. Eye Res. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8104312 Medline TA: Curr Eye Res Country: England |
Other Details:
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Languages: eng Pagination: 719-26 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, University of Rostock , Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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