Document Detail

Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy.
MedLine Citation:
PMID:  8021696     Owner:  NLM     Status:  MEDLINE    
Despite intensive searches for therapeutic agents, few substances have been convincingly shown to enhance nerve regeneration in patients with peripheral neuropathies. Recent biochemical evidence suggests that an ultra-high dose of methylcobalamin (methyl-B12) may up-regulate gene transcription and thereby protein synthesis. We examined the effects of ultra-high dose of methyl-B12 on the rate of nerve regeneration in rats with acrylamide neuropathy, using the amplitudes of compound muscle action potentials (CMAPs) after tibial nerve stimulation as an index of the number of regenerating motor fibers. After intoxication with acrylamide, all the rats showed equally decreased CMAP amplitudes. The animals were then divided into 3 groups; rats treated with ultra-high (500 micrograms/kg body weight, intraperitoneally) and low (50 micrograms/kg) doses of methyl-B12, and saline-treated control rats. Those treated with ultra-high dose showed significantly faster CMAP recovery than saline-treated control rats, whereas the low-dose group showed no difference from the control. Morphometric analysis revealed a similar difference in fiber density between these groups. Ultra-high doses of methyl-B12 may be of clinical use for patients with peripheral neuropathies.
T Watanabe; R Kaji; N Oka; W Bara; J Kimura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  122     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-07-29     Completed Date:  1994-07-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  140-3     Citation Subset:  IM    
Department of Neurology, Kyoto University Hospital, Japan.
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MeSH Terms
Acrylamides / toxicity*
Action Potentials
Body Weight / drug effects
Nerve Regeneration / drug effects*
Peripheral Nervous System Diseases / chemically induced,  drug therapy*,  physiopathology
Rats, Wistar
Tibial Nerve / physiology
Vitamin B 12 / administration & dosage,  analogs & derivatives*,  therapeutic use
Reg. No./Substance:
0/Acrylamides; 13422-55-4/mecobalamin; 68-19-9/Vitamin B 12; 79-06-1/Acrylamide

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