| Ulipristal acetate: a new emergency contraceptive that is safe and more effective than levonorgestrel. | |
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MedLine Citation:
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PMID: 21175385 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Ulipristal acetate (UPA), a selective progesterone receptor modulator, when taken as a single 30-mg dose, is safe and effective for emergency contraception up to 5 days (120 h) following unprotected intercourse. This indication has been approved in Europe since May 2009 and was approved by the US FDA in August 2010. The older progesterone-only emergency contraceptive, levonorgestrel (LNG), is approved only up to 72 h after unprotected intercourse. UPA is effective in delaying or inhibiting ovulation, even if taken 24 to 48 h prior to expected ovulation, a time when LNG is no longer effective. A recent meta-analysis of two randomized clinical trials showed UPA to have a pregnancy risk 42% lower than LNG up to 72 h, and 65% lower in the first 24 h following unprotected intercourse. In a randomized trial enrolling women up to 5 days after unprotected intercourse, significantly more pregnancies were prevented with UPA than with LNG when taken beyond 72 h. |
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Authors:
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Paul M Fine |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Women's health (London, England) Volume: 7 ISSN: 1745-5065 ISO Abbreviation: Womens Health (Lond Engl) Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101271249 Medline TA: Womens Health (Lond Engl) Country: England |
Other Details:
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Languages: eng Pagination: 9-17 Citation Subset: IM |
Affiliation:
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paul.fine@ppgulfcoast.org |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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