| Ulipristal acetate: contraceptive or contragestive? | |
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MedLine Citation:
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PMID: 21666088 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Ulipristal acetate is the first selective progesterone receptor modulator approved for postcoital contraception in the US. It appears to be significantly more effective in inhibition of ovulation than other forms of emergency contraception. However, ulipristal acetate is structurally similar to mifepristone, and several lines of evidence suggest that a postfertilization mechanism of action is also operative. This mechanism of action is considered to be contragestive versus contraceptive. Ulipristal acetate administration is contraindicated in a known or suspected pregnancy; however, it could quite possibly be used as an effective abortifacient. Health-care providers should inform patients of the possibility of both mechanisms of action with use of this drug. |
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Authors:
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Jeffrey A Keenan |
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Publication Detail:
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Type: Journal Article Date: 2011-06-10 |
Journal Detail:
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Title: The Annals of pharmacotherapy Volume: 45 ISSN: 1542-6270 ISO Abbreviation: Ann Pharmacother Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9203131 Medline TA: Ann Pharmacother Country: United States |
Other Details:
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Languages: eng Pagination: 813-5 Citation Subset: IM |
Affiliation:
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, Division of Reproductive Endocrinology and Infertility, University of Tennessee Medical Center, Knoxville, TN. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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