| Ulinastatin attenuates lung ischemia-reperfusion injury in rats by inhibiting tumor necrosis factor alpha. | |
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MedLine Citation:
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PMID: 17112827 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ischemia-reperfusion (I/R) injury may influence graft function following transplantation. Ulinastatin, a urinary trypsin inhibitor has been shown to attenuate I/R injury in various organs such as intestine, heart, and kidney in animals. The present experiment was designed to evaluate the effect of pretreatment with ulinastatin on I/R-induced lung injury. METHODS: After establishing a constant left lung warm ischemia-reperfusion model in rats, 45 animals were randomly divided into three experimental groups: sham group (n = 15), IR group (n = 15), and ulinastatin (5000 U/kg pre-ischemia) + IR group (n = 15). The lung injury was evaluated by tissue myeloperoxidase activity, with simultaneous estimation of the serum concentration of TNFalpha. RESULTS: The ulinastatin-pretreated animals exhibited markedly decreased lung tissue myeloperoxidase activity (P < .05). Blood gas analysis demonstrated, that the treated animals had significantly ameliorated pulmonary oxygenation (P < .05). The serum concentration of TNF-alpha in the ulinastatin-pretreated group was markedly decreased compared with that of the I/R group (P < .05). CONCLUSIONS: Ulinastatin attenuated I/R-induced lung injury. This function is partly related to the capacity of the agent to inhibit myeloperoxidase activity in lung tissue and decrease systemic expression to TNF-alpha. |
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Authors:
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B Ren; H Wu; J Zhu; D Li; Y Shen; R Ying; G Dong; H Jing |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Transplantation proceedings Volume: 38 ISSN: 0041-1345 ISO Abbreviation: Transplant. Proc. Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-11-20 Completed Date: 2007-02-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0243532 Medline TA: Transplant Proc Country: United States |
Other Details:
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Languages: eng Pagination: 2777-9 Citation Subset: IM |
Affiliation:
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Jinling Hospital, Clinical Medicine School of Nanjing University, Nanjing, Jiangsu, China. robbishren@yahoo.com.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Gas Analysis Disease Models, Animal Glycoproteins / therapeutic use* Male Pulmonary Circulation* Rats Rats, Sprague-Dawley Reperfusion Injury / blood, prevention & control* Trypsin Inhibitors / therapeutic use Tumor Necrosis Factor-alpha / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Glycoproteins; 0/Trypsin Inhibitors; 0/Tumor Necrosis Factor-alpha; 80449-32-7/urinastatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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