Document Detail

Ulcerative and plaque-like tracheobronchitis due to infection with Aspergillus in patients with AIDS.
MedLine Citation:
PMID:  8218674     Owner:  NLM     Status:  MEDLINE    
Tracheobronchitis is an uncommon manifestation of infection due to Aspergillus species, occurring in < 7% of cases of pulmonary aspergillosis. At least 58 cases of invasive aspergillus tracheobronchitis have been described since 1962. We describe four patients with AIDS, all of whom were severely immunocompromised, who had ulcerative tracheobronchitis due to Aspergillus species demonstrated histologically. Three patients had received corticosteroids or were neutropenic at presentation. At bronchoscopy, three patients had some degree of diffuse tracheobronchitis, multiple ulcerative or "plaque-like" inflammatory lesions, and occasionally nodules involving the mainstem and segmental bronchi. The remaining patient had a single deep ulceration of the proximal trachea. Aspergillus was isolated from biopsy specimens from all four patients. There were varied degrees of invasion of the mucosa, submucosa, and cartilage on histological examination in three patients, one of whom had evidence of disseminated aspergillosis. Two patients subsequently developed pulmonary parenchymal disease due to Aspergillus. A review of aspergillus tracheobronchitis, including a discussion of airway disease in patients infected with human immunodeficiency virus, is presented.
C A Kemper; J S Hostetler; S E Follansbee; P Ruane; D Covington; S S Leong; S C Deresinski; D A Stevens
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  17     ISSN:  1058-4838     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-12-15     Completed Date:  1993-12-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  344-52     Citation Subset:  IM; X    
Department of Medicine, Santa Clara Valley Medical Center, San Jose, California 95128.
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MeSH Terms
AIDS-Related Opportunistic Infections / microbiology*
Aspergillosis / microbiology*
Aspergillus / isolation & purification*
Bronchitis / microbiology*,  pathology
Middle Aged
Tracheitis / microbiology*,  pathology
Ulcer / microbiology,  pathology
Grant Support
N01-A1-15082//PHS HHS
Comment In:
Clin Infect Dis. 1994 Dec;19(6):1176-7   [PMID:  7888570 ]

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