| Ulcerative colitis and steroid-responsive, diffuse interstitial lung disease. A trial of N = 1. | |
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MedLine Citation:
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PMID: 3379724 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe a patient with ulcerative colitis and extracolonic manifestations in whom diffuse interstitial pulmonary disease developed that was responsive to glucocorticoid therapy one year after total proctocolectomy. The patient presented in December 1983 with a subacute course marked by cough and progressive exertional dyspnea, abnormal chest examination results, and a chest roentgenogram that revealed diffuse interstitial and alveolar infiltrates. A transbronchial biopsy specimen revealed a polymorphic interstitial infiltrate, mild interstitial fibrosis without apparent intraluminal fibrosis, and no vasculitis, granulomas, or significant eosinophilic infiltration. Within one week of the initiation of daily high-dose steroid therapy, the patient's symptoms dramatically improved; chest roentgenogram and forced vital capacity (60%) improved at a slower rate. All three measures deteriorated when alternate-day prednisone therapy was started but once again improved until the patient was totally asymptomatic, chest roentgenograms were normal, and forced vital capacity was 80% of the predicted value 2 1/2 years later. |
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Authors:
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D J Balestra; S T Balestra; J H Wasson |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: JAMA : the journal of the American Medical Association Volume: 260 ISSN: 0098-7484 ISO Abbreviation: JAMA Publication Date: 1988 Jul |
Date Detail:
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Created Date: 1988-07-15 Completed Date: 1988-07-15 Revised Date: 2006-11-07 |
Medline Journal Info:
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Nlm Unique ID: 7501160 Medline TA: JAMA Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 62-4 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Veterans Administration Medical and Regional Office Center, White River Junction, Vt. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Colitis, Ulcerative / complications* Humans Male Prednisone / therapeutic use Pulmonary Fibrosis / drug therapy, etiology*, radiography Respiratory Function Tests |
| Chemical | |
Reg. No./Substance:
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53-03-2/Prednisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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