Document Detail

Ulcerative colitis and Sweet's syndrome: a case report and review of the literature.
MedLine Citation:
PMID:  18354759     Owner:  NLM     Status:  MEDLINE    
A 47-year-old man with a history of ulcerative colitis on prednisone and azathioprine was admitted to the hospital with a four-day history of fever, skin rash, arthralgias and leukocytosis. A skin biopsy demonstrated neutrophilic infiltration of the dermis that was consistent with Sweet's syndrome. He improved after several days with an increase in his prednisone and azathioprine. Sweet's syndrome is a rare cutaneous manifestation of inflammatory bowel disease, with approximately 40 cases reported in the literature. In a previously reported case of a patient with ulcerative colitis-associated Sweet's syndrome who was on azathioprine at the time of the skin eruption, the azathioprine was stopped, raising the possibility of drug-induced Sweet's syndrome. In the present case, the azathioprine was actually increased with complete resolution of the skin manifestations. This would support the theory that immunosuppressive therapy is the mainstay of therapy for this condition. In conclusion, Sweet's syndrome is a neutrophilic dermatosis that is rarely associated with ulcerative colitis. It may occur while on immunosuppressive therapy and responds to an intensification of immunosuppression.
M Ali; D R Duerksen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Canadian journal of gastroenterology = Journal canadien de gastroenterologie     Volume:  22     ISSN:  0835-7900     ISO Abbreviation:  Can. J. Gastroenterol.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-20     Completed Date:  2008-05-29     Revised Date:  2014-01-17    
Medline Journal Info:
Nlm Unique ID:  8807867     Medline TA:  Can J Gastroenterol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  296-8     Citation Subset:  IM    
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MeSH Terms
Anti-Inflammatory Agents / administration & dosage
Azathioprine / administration & dosage
Colitis, Ulcerative / complications*,  drug therapy
Immunosuppressive Agents / administration & dosage
Middle Aged
Prednisone / administration & dosage
Sweet Syndrome / drug therapy,  etiology*
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Immunosuppressive Agents; MRK240IY2L/Azathioprine; VB0R961HZT/Prednisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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