| The Ukrainian-American study of leukemia and related disorders among Chornobyl cleanup workers from Ukraine: I. Study methods. | |
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MedLine Citation:
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PMID: 19138036 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There are relatively few data on the risk of leukemia among those exposed to external radiation during cleanup operations after the Chornobyl nuclear accident, and results have not been consistent. To investigate this further, we assembled a cohort of 110,645 male cleanup workers from Ukraine and identified cases of leukemia occurring during the period 1986 to 2000. Detailed interviews were conducted and individual bone marrow doses estimated using a new time-and-motion method known as RADRUE described in companion paper II. For the initial analyses we used a nested case-control approach with a minimum of five controls per case, matched for year of birth, oblast (region) of registration, and residence. All identified cases were reviewed by an international panel of experts; 87 of 111 were confirmed. The dose-response analysis and results are given in companion paper III. As background, we describe herein the design, procedures, outcome of case finding and confirmation, control selection, dose estimation and interviewing of subjects. |
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Authors:
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A Romanenko; V Bebeshko; M Hatch; D Bazyka; S Finch; I Dyagil; R Reiss; V Chumak; A Bouville; N Gudzenko; L Zablotska; M Pilinskaya; T Lyubarets; E Bakhanova; N Babkina; N Trotsiuk; B Ledoschuk; Y Belayev; S S Dybsky; E Ron; G Howe |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Radiation research Volume: 170 ISSN: 0033-7587 ISO Abbreviation: Radiat. Res. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2009-01-13 Completed Date: 2009-02-06 Revised Date: 2010-09-23 |
Medline Journal Info:
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Nlm Unique ID: 0401245 Medline TA: Radiat Res Country: United States |
Other Details:
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Languages: eng Pagination: 691-7 Citation Subset: IM; S |
Affiliation:
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Research Center for Radiation Medicine, Kyiv, Ukraine. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Distribution Aged Aged, 80 and over Case-Control Studies Chernobyl Nuclear Accident* Cities / epidemiology Cohort Studies Dose-Response Relationship, Radiation Environmental Remediation* Epidemiologic Research Design Humans Leukemia / epidemiology* Male Middle Aged Multiple Myeloma / epidemiology* Myelodysplastic Syndromes / epidemiology* Neoplasms, Radiation-Induced / epidemiology* Occupational Exposure* Risk Factors Ukraine / epidemiology United States |
| Grant Support | |
ID/Acronym/Agency:
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Z01 CP010133-13/CP/NCI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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