Document Detail


The Ukrainian-American study of leukemia and related disorders among Chornobyl cleanup workers from Ukraine: I. Study methods.
MedLine Citation:
PMID:  19138036     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There are relatively few data on the risk of leukemia among those exposed to external radiation during cleanup operations after the Chornobyl nuclear accident, and results have not been consistent. To investigate this further, we assembled a cohort of 110,645 male cleanup workers from Ukraine and identified cases of leukemia occurring during the period 1986 to 2000. Detailed interviews were conducted and individual bone marrow doses estimated using a new time-and-motion method known as RADRUE described in companion paper II. For the initial analyses we used a nested case-control approach with a minimum of five controls per case, matched for year of birth, oblast (region) of registration, and residence. All identified cases were reviewed by an international panel of experts; 87 of 111 were confirmed. The dose-response analysis and results are given in companion paper III. As background, we describe herein the design, procedures, outcome of case finding and confirmation, control selection, dose estimation and interviewing of subjects.
Authors:
A Romanenko; V Bebeshko; M Hatch; D Bazyka; S Finch; I Dyagil; R Reiss; V Chumak; A Bouville; N Gudzenko; L Zablotska; M Pilinskaya; T Lyubarets; E Bakhanova; N Babkina; N Trotsiuk; B Ledoschuk; Y Belayev; S S Dybsky; E Ron; G Howe
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Radiation research     Volume:  170     ISSN:  0033-7587     ISO Abbreviation:  Radiat. Res.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-01-13     Completed Date:  2009-02-06     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  0401245     Medline TA:  Radiat Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  691-7     Citation Subset:  IM; S    
Affiliation:
Research Center for Radiation Medicine, Kyiv, Ukraine.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Case-Control Studies
Chernobyl Nuclear Accident*
Cities / epidemiology
Cohort Studies
Dose-Response Relationship, Radiation
Environmental Remediation*
Epidemiologic Research Design
Humans
Leukemia / epidemiology*
Male
Middle Aged
Multiple Myeloma / epidemiology*
Myelodysplastic Syndromes / epidemiology*
Neoplasms, Radiation-Induced / epidemiology*
Occupational Exposure*
Risk Factors
Ukraine / epidemiology
United States
Grant Support
ID/Acronym/Agency:
Z01 CP010133-13/CP/NCI NIH HHS
Comments/Corrections

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