Document Detail


Ubiquitylation and the pathogenesis of hypertension.
MedLine Citation:
PMID:  23348731     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Liddle syndrome is monogenic hypertension caused by mutations in the epithelial Na+ channel (ENaC) that interfere with its ubiquitylation by Nedd4-2. In this issue, Ronzaud and colleagues found that deleting Nedd4-2 from kidney tubules in adult mice led to ENaC accumulation, but not at the plasma membrane, as predicted from current models. Instead, abundance of the sodium chloride transporter NCC increased at the plasma membrane, and the mice have some features of increased NCC activity. Together, the results suggest that defective ubiquitylation of ENaC by Nedd4-2 may not fully explain Liddle syndrome and that Nedd4-2 modulates NCC more strongly.
Authors:
David H Ellison
Publication Detail:
Type:  Comment; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2013-01-25
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  123     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-04-19     Completed Date:  2013-05-13     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  546-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Endosomal Sorting Complexes Required for Transport / deficiency*
Humans
Hypertension / etiology*
Kidney Tubules / physiopathology*
Receptors, Drug / metabolism*
Solute Carrier Family 12, Member 3
Symporters / metabolism*
Ubiquitin-Protein Ligases / deficiency*
Grant Support
ID/Acronym/Agency:
DK 1 RO1 095841/DK/NIDDK NIH HHS; DK 5 RO1 51496/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Endosomal Sorting Complexes Required for Transport; 0/Receptors, Drug; 0/Slc12a3 protein, mouse; 0/Solute Carrier Family 12, Member 3; 0/Symporters; EC 6.3.2.19/Nedd4 ubiquitin protein ligases; EC 6.3.2.19/Ubiquitin-Protein Ligases
Comments/Corrections
Comment On:
J Clin Invest. 2013 Feb 1;123(2):657-65   [PMID:  23348737 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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