Document Detail


Ubiquitous somatic alterations at microsatellite alleles occur infrequently in Barrett's-associated esophageal adenocarcinoma.
MedLine Citation:
PMID:  8542577     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Microsatellite alterations have been documented in a subset of sporadic tumors, including those of the colon, lung, bladder, stomach, and esophagus. This study documented the frequency of microsatellite alterations at 139 loci, comprising predominantly dinucleotide and tetranucleotide repeat units, in 17 cases of primary esophageal adenocarcinoma arising against a background of Barrett's metaplasia. Each tumor demonstrated alterations in at least one locus studied. Widespread microsatellite alterations, occurring at 45.3% (58 of 128) of loci tested, were detected in a single case. The remaining 16 tumors exhibited low levels of microsatellite instability, ranging from 0.8% (1 of 128) to 8.1% (10 of 123) of loci tested. The single case with ubiquitous somatic alterations showed no significant difference in the incidence of novel alleles at di- and tetranucleotide repeat loci. The 16 cases showing a low level of microsatellite alterations demonstrated a 3.3-fold higher incidence of novel alleles at tetranucleotide repeat loci compared to dinucleotide repeat loci. These data suggest that ubiquitous somatic alterations at microsatellite loci, considered a phenotypic expression of defective mismatch repair, occur infrequently in Barrett's-associated adenocarcinoma. However, the majority of these tumors demonstrate a low level of microsatellite alterations, perhaps reflecting the inherent instability of these markers.
Authors:
C M Gleeson; J M Sloan; J A McGuigan; A J Ritchie; J L Weber; S E Russell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer research     Volume:  56     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-02-13     Completed Date:  1996-02-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  259-63     Citation Subset:  IM    
Affiliation:
Department of Medical Genetics, Queen's University of Belfast, Belfast City Hospital, Northern Ireland.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / etiology,  genetics*
Adult
Aged
Alleles*
Barrett Esophagus / complications,  genetics*
DNA, Neoplasm / genetics
DNA, Satellite / genetics*
Esophageal Neoplasms / etiology,  genetics*
Female
Humans
Male
Microsatellite Repeats / genetics*
Middle Aged
Grant Support
ID/Acronym/Agency:
HG00835/HG/NHGRI NIH HHS
Chemical
Reg. No./Substance:
0/DNA, Neoplasm; 0/DNA, Satellite

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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