| Ubiquitous presence of gluconeogenic regulatory enzyme, fructose-1,6-bisphosphatase, within layers of rat retina. | |
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MedLine Citation:
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PMID: 20614135 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To shed some light on gluconeogenesis in mammalian retina, we have focused on fructose-1,6-bisphosphatase (FBPase), a regulatory enzyme of the process. The abundance of the enzyme within the layers of the rat retina suggests that, in mammals in contrast to amphibia, gluconeogenesis is not restricted to one specific cell of the retina. We propose that FBPase, in addition to its gluconeogenic role, participates in the protection of the retina against reactive oxygen species. Additionally, the nuclear localization of FBPase and of its binding partner, aldolase, in the retinal cells expressing the proliferation marker Ki-67 indicates that these two gluconeogenic enzymes are involved in non-enzymatic nuclear processes. |
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Authors:
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Piotr Mamczur; Jakub Mazurek; Darek Rakus |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-08 |
Journal Detail:
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Title: Cell and tissue research Volume: 341 ISSN: 1432-0878 ISO Abbreviation: Cell Tissue Res. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-03 Completed Date: 2010-11-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417625 Medline TA: Cell Tissue Res Country: Germany |
Other Details:
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Languages: eng Pagination: 213-21 Citation Subset: IM |
Affiliation:
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Department of Animal Molecular Physiology, Institute of Zoology, Wroclaw University, Cybulskiego 30, 50-205, Wroclaw, Poland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Astrocytes / enzymology, metabolism Cell Nucleus / enzymology*, metabolism Fructose / metabolism Fructose-Bisphosphatase / chemistry, metabolism* Fructose-Bisphosphate Aldolase / chemistry, metabolism Gluconeogenesis / physiology* Glucose / metabolism Glycogen / metabolism Isoenzymes / metabolism Ki-67 Antigen / genetics, physiology Rats Reactive Oxygen Species / metabolism Retina / enzymology*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Isoenzymes; 0/Ki-67 Antigen; 0/Reactive Oxygen Species; 30237-26-4/Fructose; 50-99-7/Glucose; 9005-79-2/Glycogen; EC 3.1.3.11/Fructose-Bisphosphatase; EC 4.1.2.13/Fructose-Bisphosphate Aldolase |
| Comments/Corrections | |
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