Document Detail


Ubiquitination is associated with lysosomal degradation of cell surface-resident ATP-binding cassette transporter A1 (ABCA1) through the endosomal sorting complex required for transport (ESCRT) pathway.
MedLine Citation:
PMID:  21520210     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: Together with the fact that lysosomal inhibitor treatments increased ABCA1 expression in HuH-7 and THP-1 macrophages, these results suggest that ubiquitination mediates the lysosomal degradation of cell surface-resident ABCA1 through the ESCRT pathway, and thereby controls the expression and cholesterol efflux function of ABCA1. This mechanism seems to mediate ABCA1 degradation independently of the calpain-involving pathway. The modulation of ABCA1 ubiquitination could thus be a potential new therapeutic target for antiatherogenic drugs.
Authors:
Tadahaya Mizuno; Hisamitsu Hayashi; Sotaro Naoi; Yuichi Sugiyama
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-06-26
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  54     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-27     Completed Date:  2011-09-30     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  631-43     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Association for the Study of Liver Diseases.
Affiliation:
Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
ATP-Binding Cassette Transporters / metabolism*
Animals
Cell Line, Tumor
Endosomal Sorting Complexes Required for Transport / physiology*
Humans
Lysosomes / metabolism*
Mice
Signal Transduction
Tumor Cells, Cultured
Ubiquitination*
Chemical
Reg. No./Substance:
0/ATP binding cassette transporter 1; 0/Endosomal Sorting Complexes Required for Transport

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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