| Ubiquitination is associated with lysosomal degradation of cell surface-resident ATP-binding cassette transporter A1 (ABCA1) through the endosomal sorting complex required for transport (ESCRT) pathway. | |
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MedLine Citation:
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PMID: 21520210 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONCLUSION: Together with the fact that lysosomal inhibitor treatments increased ABCA1 expression in HuH-7 and THP-1 macrophages, these results suggest that ubiquitination mediates the lysosomal degradation of cell surface-resident ABCA1 through the ESCRT pathway, and thereby controls the expression and cholesterol efflux function of ABCA1. This mechanism seems to mediate ABCA1 degradation independently of the calpain-involving pathway. The modulation of ABCA1 ubiquitination could thus be a potential new therapeutic target for antiatherogenic drugs. |
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Authors:
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Tadahaya Mizuno; Hisamitsu Hayashi; Sotaro Naoi; Yuichi Sugiyama |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-06-26 |
Journal Detail:
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Title: Hepatology (Baltimore, Md.) Volume: 54 ISSN: 1527-3350 ISO Abbreviation: Hepatology Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-27 Completed Date: 2011-09-30 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 8302946 Medline TA: Hepatology Country: United States |
Other Details:
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Languages: eng Pagination: 631-43 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 American Association for the Study of Liver Diseases. |
Affiliation:
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Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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ATP-Binding Cassette Transporters
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metabolism* Animals Cell Line, Tumor Endosomal Sorting Complexes Required for Transport / physiology* Humans Lysosomes / metabolism* Mice Signal Transduction Tumor Cells, Cultured Ubiquitination* |
| Chemical | |
Reg. No./Substance:
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0/ATP binding cassette transporter 1; 0/Endosomal Sorting Complexes Required for Transport |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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