Document Detail


Ubiquitin-specific protease activity of USP9Y, a male infertility gene on the Y chromosome.
MedLine Citation:
PMID:  12895410     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Deletions of USP9Y have been observed among infertile males with defective spermatogenesis. Therefore, the gene has been designated as a male infertility gene on the Y chromosome. However, it remains to be determined how male infertility results from deletions of this gene. In order to initiate an investigation into the cellular functions of USP9Y in male germ cell development, in the present study we characterized the enzymatic specificity of USP9Y. Our results show that both USP9Y and Fam, the mouse infertility protein Usp9x, possess a protease activity specific to ubiquitin. These results suggest that, through de-ubiquitination, USP9Y may stabilize a specific target protein that is important for male germ cell development.
Authors:
Kyung Ho Lee; Gyun Jee Song; Inn Soo Kang; Soo Woong Kim; Jae-Seung Paick; Chin Ha Chung; Kunsoo Rhee
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Reproduction, fertility, and development     Volume:  15     ISSN:  1031-3613     ISO Abbreviation:  Reprod. Fertil. Dev.     Publication Date:  2003  
Date Detail:
Created Date:  2003-08-04     Completed Date:  2005-03-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8907465     Medline TA:  Reprod Fertil Dev     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  129-33     Citation Subset:  IM    
Affiliation:
School of Biological Sciences, Seoul National University, Seoul 151-742, Korea.
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MeSH Terms
Descriptor/Qualifier:
Animals
COS Cells
Cercopithecus aethiops
Chromosomes, Human, Y
Endopeptidases / genetics,  metabolism*
Escherichia coli / genetics,  growth & development
Humans
Infertility, Male / enzymology*,  genetics
Male
Mice
Recombinant Proteins / metabolism
Substrate Specificity
Transfection
Transformation, Bacterial
Ubiquitin / metabolism
Ubiquitin Thiolesterase
Chemical
Reg. No./Substance:
0/Recombinant Proteins; 0/Ubiquitin; EC 3.1.2.15/USP7 protein, human; EC 3.1.2.15/USP9Y protein, human; EC 3.1.2.15/Ubiquitin Thiolesterase; EC 3.4.-/Endopeptidases; EC 3.4.99.-/Usp9x protein, mouse

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