| Ubiquitin-specific protease activity of USP9Y, a male infertility gene on the Y chromosome. | |
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MedLine Citation:
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PMID: 12895410 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Deletions of USP9Y have been observed among infertile males with defective spermatogenesis. Therefore, the gene has been designated as a male infertility gene on the Y chromosome. However, it remains to be determined how male infertility results from deletions of this gene. In order to initiate an investigation into the cellular functions of USP9Y in male germ cell development, in the present study we characterized the enzymatic specificity of USP9Y. Our results show that both USP9Y and Fam, the mouse infertility protein Usp9x, possess a protease activity specific to ubiquitin. These results suggest that, through de-ubiquitination, USP9Y may stabilize a specific target protein that is important for male germ cell development. |
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Authors:
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Kyung Ho Lee; Gyun Jee Song; Inn Soo Kang; Soo Woong Kim; Jae-Seung Paick; Chin Ha Chung; Kunsoo Rhee |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Reproduction, fertility, and development Volume: 15 ISSN: 1031-3613 ISO Abbreviation: Reprod. Fertil. Dev. Publication Date: 2003 |
Date Detail:
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Created Date: 2003-08-04 Completed Date: 2005-03-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8907465 Medline TA: Reprod Fertil Dev Country: Australia |
Other Details:
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Languages: eng Pagination: 129-33 Citation Subset: IM |
Affiliation:
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School of Biological Sciences, Seoul National University, Seoul 151-742, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals COS Cells Cercopithecus aethiops Chromosomes, Human, Y Endopeptidases / genetics, metabolism* Escherichia coli / genetics, growth & development Humans Infertility, Male / enzymology*, genetics Male Mice Recombinant Proteins / metabolism Substrate Specificity Transfection Transformation, Bacterial Ubiquitin / metabolism Ubiquitin Thiolesterase |
| Chemical | |
Reg. No./Substance:
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0/Recombinant Proteins; 0/Ubiquitin; EC 3.1.2.15/USP7 protein, human; EC 3.1.2.15/USP9Y protein, human; EC 3.1.2.15/Ubiquitin Thiolesterase; EC 3.4.-/Endopeptidases; EC 3.4.99.-/Usp9x protein, mouse |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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