Document Detail

Ubiquitin-positive foam cells are identified in the aortic and mitral valves with atherosclerotic involvement.
MedLine Citation:
PMID:  19729866     Owner:  NLM     Status:  MEDLINE    
AIM: Our aim was to determine the roles of the ubiquitin (Ub)-proteasome system (UPS) in valvular diseases by immunohistochemically identifying Ub-positive cells in aortic and mitral valves and determining if Ub+cells were associated with the severity of valvular diseases. METHODS: We evaluated surgically removed aortic and mitral valves from 60 patients (mean age, 64.5 years) for thickening, fibrosis, foam cell infiltration, thrombus, and atheromatous plaques by using grading scores. U+cells were detected immunohistochemically. RESULTS: We found Ub+cells in 16 (26.7%) of the 60 patients. Eleven (28.2%) of the 39 aortic valves and 5 (23.8%) of the 21 mitral valves were Ub-positive. Ub was found with granular depositions in the cytoplasm of monocyte-derived foam cells that were CD68+. The aortic valvular thickness of the Ub+group was significantly greater than that of the Ub- group (3.9+/-1.6mm vs. 3.2+/-1.6mm, p<0.05). Foam cells and fibrosis were greater in the Ub+group (p<0.05), and calcifications were prominent in aortic valves. There was no difference in the number of apoptotic cells in Ub+ and Ub- groups. Ub+cells were present in the affected valves and ubiquitinated proteins were accumulated in macrophage-derived foam cells. CONCLUSIONS: Ub+ foam cells are present in valves that are vulnerable to valvular disease, and UPS may contribute to the development of atherosclerosis through the inflammatory process.
Tsutomu Yamada; Suetaka Satoh; Sumihisa Sueyoshi; Masako Mitsumata; Taro Matsumoto; Takahiro Ueno; Kenji Uehara; Tomohiko Mizutani
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Publication Detail:
Type:  Journal Article     Date:  2009-09-03
Journal Detail:
Title:  Journal of atherosclerosis and thrombosis     Volume:  16     ISSN:  1880-3873     ISO Abbreviation:  J. Atheroscler. Thromb.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-09-16     Completed Date:  2009-12-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506298     Medline TA:  J Atheroscler Thromb     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  472-9     Citation Subset:  IM    
Department of Pathology, Nihon University School of Medicine, Tokyo, Japan.
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MeSH Terms
Aged, 80 and over
Aortic Valve / chemistry,  pathology*
Atherosclerosis / pathology*
Foam Cells / chemistry*,  pathology
Middle Aged
Mitral Valve / chemistry,  pathology*
Proteasome Endopeptidase Complex
Severity of Illness Index
Ubiquitin / analysis*
Ubiquitinated Proteins / analysis
Reg. No./Substance:
0/Ubiquitin; 0/Ubiquitinated Proteins; EC Endopeptidase Complex

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